Next Article in Journal
Further Insights on the Carotenoid Profile of the Echinoderm Marthasterias glacialis L.
Previous Article in Journal
The Use of UV-Visible Reflectance Spectroscopy as an Objective Tool to Evaluate Pearl Quality
Open AccessReview

Algal Lectins as Potential HIV Microbicide Candidates

Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium
Author to whom correspondence should be addressed.
Mar. Drugs 2012, 10(7), 1476-1497;
Received: 25 May 2012 / Revised: 22 June 2012 / Accepted: 29 June 2012 / Published: 10 July 2012
The development and use of topical microbicides potentially offers an additional strategy to reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding agents (CBAs) that show specificity for high mannose carbohydrates on the surface of the heavily glycosylated envelope of HIV are endowed with potent anti-HIV activity. In fact, a number of algal lectins such as cyanovirin-N, microvirin, microcystis viridis lectin, scytovirin, Oscillatoria agardhii agglutinin and griffithsin are considered as potential microbicide candidates to prevent the sexual transmission of HIV through topical applications. They not only inhibit infection of cells by cell-free virus but they can also efficiently prevent virus transmission from virus-infected cells to uninfected CD4+ target T-lymphocytes and DC-SIGN-directed capture of HIV-1 and transmission to CD4+ T lymphocytes. This review focuses on the structural properties and carbohydrate specificity of these algal lectins, their antiviral activity against HIV and several other enveloped viruses, their safety profile and viral resistance patterns. View Full-Text
Keywords: algae; lectin; carbohydrate-binding agents; HIV; virus entry; gp120 envelope; microbicide algae; lectin; carbohydrate-binding agents; HIV; virus entry; gp120 envelope; microbicide
Show Figures

Figure 1

MDPI and ACS Style

Huskens, D.; Schols, D. Algal Lectins as Potential HIV Microbicide Candidates. Mar. Drugs 2012, 10, 1476-1497.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop