Next Article in Journal / Special Issue
Pigmentation and Spectral Absorbance Signatures in Deep-Water Corals from the Trondheimsfjord, Norway
Previous Article in Journal
Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator
Previous Article in Special Issue
Dietary Carotenoids Regulate Astaxanthin Content of Copepods and Modulate Their Susceptibility to UV Light and Copper Toxicity
Open AccessArticle

Anti-Oxidative, Anti-Tumor-Promoting, and Anti-Carcinogensis Activities of Nitroastaxanthin and Nitrolutein, the Reaction Products of Astaxanthin and Lutein with Peroxynitrite

1
Research Institute for Production Development, 15 Shimogamo-morimoto-cho, Sakyo-ku, Kyoto 606-0805, Japan
2
Department of Complementary and Alternative Medicine, Clinical R&D, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
3
Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan
*
Author to whom correspondence should be addressed.
Mar. Drugs 2012, 10(6), 1391-1399; https://doi.org/10.3390/md10061391
Received: 29 March 2012 / Revised: 7 June 2012 / Accepted: 13 June 2012 / Published: 18 June 2012
(This article belongs to the Special Issue Marine Carotenoids and Oxidative Stress)
Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin showed excellent singlet oxygen quenching activity. Furthermore, 15-nitroastaxanthin showed inhibitory effects of in vitro Epstein-Barr virus early antigen activation and two-stage carcinogensis on mouse skin papillomas. These activities were slightly higher than those of astaxanthin. Similar results were obtained for the 15-nitrolutein, a major reaction product of lutein with peroxynitrite. View Full-Text
Keywords: carotenoid; 15-nitroastaxanthin; 15-nitrolutein; anti-carcinogensis activity; anti-oxidative activity carotenoid; 15-nitroastaxanthin; 15-nitrolutein; anti-carcinogensis activity; anti-oxidative activity
Show Figures

Figure 1

MDPI and ACS Style

Maoka, T.; Tokuda, H.; Suzuki, N.; Kato, H.; Etoh, H. Anti-Oxidative, Anti-Tumor-Promoting, and Anti-Carcinogensis Activities of Nitroastaxanthin and Nitrolutein, the Reaction Products of Astaxanthin and Lutein with Peroxynitrite. Mar. Drugs 2012, 10, 1391-1399.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop