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Mar. Drugs 2012, 10(2), 340-348;

Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321

School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China
CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Rd., Guangzhou 510301, China
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-Sen University), Bureau of Education of Guangdong, Guangzhou, 510275, China
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China
Syngenta Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK
Authors to whom correspondence should be addressed.
Received: 2 December 2011 / Revised: 17 January 2012 / Accepted: 17 January 2012 / Published: 6 February 2012
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Three new eremophilane sesquiterpenes (13) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC50 value is 6.54 μM. View Full-Text
Keywords: marine fungus; Xylaria sp.; mangrove; sesquiterpenes; α-glucosidase marine fungus; Xylaria sp.; mangrove; sesquiterpenes; α-glucosidase

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Song, Y.; Wang, J.; Huang, H.; Ma, L.; Wang, J.; Gu, Y.; Liu, L.; Lin, Y. Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321. Mar. Drugs 2012, 10, 340-348.

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