Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis
by
Yongxin Li 1, Ying Xu 1, Lingli Liu 1, Zhuang Han 1, Pok Yui Lai 1, Xiangrong Guo 2, Xixiang Zhang 2, Wenhan Lin 3
and Pei-Yuan Qian 1,*
Yongxin Li 1, Ying Xu 1, Lingli Liu 1, Zhuang Han 1, Pok Yui Lai 1, Xiangrong Guo 2, Xixiang Zhang 2, Wenhan Lin 3 and Pei-Yuan Qian 1,*
1
KAUST Global Collaborative Research, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
2
Advanced Nano-fabrication, Imaging & Characterization Core lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
3
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2012, 10(2), 319-328; https://doi.org/10.3390/md10020319
Received: 20 December 2011 / Revised: 29 January 2012 / Accepted: 30 January 2012 / Published: 3 February 2012
Four novel amicoumacins, namely lipoamicoumacins A–D (1–4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature.
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Keywords:
antibacterial; cytotoxicity; lipoamicoumacin; Bacillus subtilis
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This is an open access article distributed under the Creative Commons Attribution License
MDPI and ACS Style
Li, Y.; Xu, Y.; Liu, L.; Han, Z.; Lai, P.Y.; Guo, X.; Zhang, X.; Lin, W.; Qian, P.-Y. Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis. Mar. Drugs 2012, 10, 319-328.
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