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Open AccessArticle

Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis

1
Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
2
Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China
3
Advanced Nano-Fabrication, Imaging and Characterization Core Lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2012, 10(11), 2571-2583; https://doi.org/10.3390/md10112571
Received: 20 September 2012 / Revised: 8 November 2012 / Accepted: 12 November 2012 / Published: 20 November 2012
Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. View Full-Text
Keywords: Streptomyces caelestis; citreamicin; antibacterial; MRSA Streptomyces caelestis; citreamicin; antibacterial; MRSA
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Liu, L.-L.; Xu, Y.; Han, Z.; Li, Y.-X.; Lu, L.; Lai, P.-Y.; Zhong, J.-L.; Guo, X.-R.; Zhang, X.-X.; Qian, P.-Y. Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Mar. Drugs 2012, 10, 2571-2583.

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