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Open AccessArticle

Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

1
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan
2
Scientific Crime Laboratory, Tottori Prefectural Police H. Q., 2-12 Chiyomi, Tottori 680-0911, Japan
3
The Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan
4
Marine Products Kimura Co., LTD., 3307 Watari-cho Sakaiminato-shi, Tottori 684-0072, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2012, 10(10), 2337-2348; https://doi.org/10.3390/md10102337
Received: 17 August 2012 / Revised: 10 September 2012 / Accepted: 11 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Marine Glycoconjugates)
We evaluated the anti-tumor activities of the oral administration of fucoidan extracted from Cladosiphon okamuranus using a tumor (colon 26)-bearing mouse model. The materials used included low-molecular-weight fucoidan (LMWF: 6.5–40 kDa), intermediate-molecular-weight fucoidan (IMWF: 110–138 kDa) and high-molecular-weight fucoidan (HMWF: 300–330 kDa). The IMWF group showed significantly suppressed tumor growth. The LMWF and HMWF groups showed significantly increased survival times compared with that observed in the control group (mice fed a fucoidan-free diet). The median survival times in the control, LMWF, IMWF and HMWF groups were 23, 46, 40 and 43 days, respectively. It was also found that oral administration of fucoidan increased the population of natural killer cells in the spleen. Furthermore, from the results of the experiment using Myd-88 knockout mice, it was found that these effects are related to gut immunity. These results suggest that fucoidan is a candidate anti-tumor functional food. View Full-Text
Keywords: fucoidan; Cladosiphon okamuranu; anti-tumor activities; colon-26; mice; functional food fucoidan; Cladosiphon okamuranu; anti-tumor activities; colon-26; mice; functional food
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Azuma, K.; Ishihara, T.; Nakamoto, H.; Amaha, T.; Osaki, T.; Tsuka, T.; Imagawa, T.; Minami, S.; Takashima, O.; Ifuku, S.; Morimoto, M.; Saimoto, H.; Kawamoto, H.; Okamoto, Y. Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model. Mar. Drugs 2012, 10, 2337-2348.

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