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Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity

Department of Chemistry, University of California, Davis, California 95616, USA
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Mar. Drugs 2003, 1(1), 46-53; https://doi.org/10.3390/md101046
Received: 13 October 2003 / Accepted: 13 November 2003 / Published: 26 November 2003
Two new long-chain C33 polyacetylenic compounds, halicynones A and B were isolated from the marine sponge Haliclona sp. along with known analogs. The known compound pellynol A possessing a 1-yn-3-ol terminus, exhibited strong antitumor activity against the human colon tumor cell line HCT-116 (IC50 0.026 μg/mL), however, the corresponding 1-yn-3-one, halicynone A, was inactive, which suggests an important role for the terminal 1-yn-3-ol functional group in mediating cytotoxic activity. View Full-Text
Keywords: Porifera; ene-yne; HCT-116; cytotoxic activity; polyacetylene; pellynol Porifera; ene-yne; HCT-116; cytotoxic activity; polyacetylene; pellynol
MDPI and ACS Style

Zhou, G.-X.; Molinski, T.F. Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity. Mar. Drugs 2003, 1, 46-53.

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