Trends in Myocardial Infarction Morbidity and Mortality from Ischemic Heart Disease in Middle-Aged Lithuanian Population from 2000 to 2023: Data from Population-Based Kaunas Ischemic Heart Disease Register
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Sample
2.2. Ascertainment of Outcome Events
2.3. Statistical Analysis
2.4. Ethical Approval
3. Results
4. Discussion
Strengths and Limitations of the Study
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Timmis, A.; Townsend, N.; Gale, C.P.; Torbica, A.; Lettino, M.; Petersen, S.E.; Mossialos, E.A.; Maggioni, A.P.; Kazakiewicz, D.; May, H.T.; et al. European Society of Cardiology: Cardiovascular Disease Statistics 2019. Eur. Heart J. 2020, 41, 12–85. [Google Scholar] [CrossRef] [PubMed]
- Menotti, A.; Puddu, P.E.; Tolonen, H.; Kafatos, A. Cardiovascular mortality in northern and southern European cohorts of the seven countries study at 60-year follow-up. J. Cardiovasc. Med. 2023, 24, 96–104. [Google Scholar] [CrossRef]
- Zuin, M.; Rigatelli, G.; Temporelli, P.; Di Fusco, S.A.; Colivicchi, F.; Pasquetto, G.; Bilato, C. Trends in acute myocardial infarction mortality in the European Union, 2012–2020. Eur. J. Prev. Cardiol. 2023, 30, 1758–1771. [Google Scholar] [CrossRef]
- Li, Y.; Cao, G.Y.; Jing, W.Z.; Liu, J.; Liu, M. Global trends and regional differences in incidence and mortality of cardiovascular disease, 1990–2019: Findings from 2019 global burden of disease study. Eur. J. Prev. Cardiol. 2023, 30, 276–286. [Google Scholar] [CrossRef]
- Mensah, G.A.; Fuster, V.; Murray, C.J.L.; Roth, G.A. Global Burden of Cardiovascular Diseases and Risks Collaborators. Global Burden of Cardiovascular Diseases and Risks, 1990–2022. J. Am. Coll. Cardiol. 2023, 82, 2350–2473. [Google Scholar] [CrossRef]
- Sulo, G.; Igland, J.; Vollset, S.E.; Ebbing, M.; Egeland, G.M.; Ariansen, I.; Tell, G.S. Trends in incident acute myocardial infarction in Norway: An updated analysis to 2014 using national data from the CVDNOR project. Eur. J. Prev. Cardiol. 2018, 25, 1031–1039. [Google Scholar] [CrossRef] [PubMed]
- Beller, J.; Bauersachs, J.; Schäfer, A.; Schwettmann, L.; Heier, M.; Peters, A.; Meisinger, C.; Geyer, S. Diverging Trends in Age at First Myocardial Infarction: Evidence from Two German Population-Based Studies. Sci. Rep. 2020, 10, 9610. [Google Scholar] [CrossRef]
- Krämer, C.; Meisinger, C.; Kirchberger, I.; Heier, M.; Kuch, B.; Thilo, C.; Linseisen, J.; Amann, U. Epidemiological trends in mortality, event rates and case fatality of acute myocardial infarction from 2004 to 2015: Results from the KORA MI registry. Ann. Med. 2021, 53, 2142–2152. [Google Scholar] [CrossRef] [PubMed]
- Wright, F.L.; Townsend, N.; Greenland, M.; Goldacre, M.J.; Smolina, K.; Lacey, B.; Nedkoff, L. Long-term trends in population-based hospitalisation rates for myocardial infarction in England: A national database study of 3.5 million admissions, 1968–2016. J. Epidemiol. Community Health 2022, 76, 45–52. [Google Scholar] [CrossRef]
- Christensen, D.M.; Strange, J.E.; Phelps, M.; Schjerning, A.M.; Sehested, T.S.G.; Gerds, T.; Gislason, G. Age- and sex-specific trends in the incidence of myocardial infarction in Denmark, 2005 to 2021. Atherosclerosis 2022, 346, 63–67. [Google Scholar] [CrossRef]
- Zuin, M.; Tadiello, E.; Toniolo, S.; Loddo, I.; Tenaglia, R.M.; Bilato, C. Andamento temporale della mortalità da infarto miocardico acuto in Italia (2007–2017) [Temporal trends in acute myocardial infarction-related mortality in Italy (2007–2017)]. G. Ital. Cardiol. 2023, 24, 373–379. (In Italian) [Google Scholar]
- Camps-Vilaró, A.; Subirana, I.; Elosua, R.; Palomo, I.; Sanchis, J.; Tizón-Marcos, H.; Cainzos-Achirica, M.; Sala, J.; Masia, R.; Ramos, R.; et al. Analysis of myocardial infarction incidence and case-fatality in the last three decades in the province of Girona. Rev. Esp. Cardiol. Engl. Ed. 2024, 77, 450–458, (In English, Spanish). [Google Scholar] [CrossRef]
- Meyer, A.C.; Ebeling, M.; Acosta, E.; Modig, K. Continued decline in the incidence of myocardial infarction beyond the COVID-19 pandemic: A nationwide study of the Swedish population aged 60 and older during 2015–2022. Eur. J. Epidemiol. 2024, 39, 605–612. [Google Scholar] [CrossRef] [PubMed]
- Gierlotka, M.; Zdrojewski, T.; Wojtyniak, B.; Poloński, L.; Stokwiszewski, J.; Gąsior, M.; Kozierkiewicz, A.; Kalarus, Z.; Wierucki, Ł.; Chlebus, K.; et al. Incidence, treatment, in-hospital mortality and one-year outcomes of acute myocardial infarction in Poland in 2009–2012–nationwide AMI-PL database. Kardiol. Pol. 2015, 73, 142–158. [Google Scholar] [CrossRef] [PubMed]
- Zhdan, V.M.; Oksak, G.A.; Radomskyi, O.V.; Shaposhnikov, D.I. Epidemiology of acute myocardial infarction in Ukraine and Poltava region. Wiad. Lek. 2018, 71, 751–756. [Google Scholar]
- Ioacara, S.; Popescu, A.C.; Tenenbaum, J.; Dimulescu, D.R.; Popescu, M.R.; Sirbu, A.; Fica, S. Acute Myocardial Infarction Mortality Rates and Trends in Romania between 1994 and 2017. Int. J. Environ. Res. Public Health 2019, 17, 285. [Google Scholar] [CrossRef]
- Bruthans, J.; Mayer, O.; Jarkovsky, J.; Zvolsky, M.; Bruthans, J. Long-term trends in the incidence, treatment, hospital fatality and subsequent mortality from acute myocardial infarction in the Czech Republic. Biomed. Pap. Med. Fac. Palacky Univ. Olomouc 2021, 165, 283–290. [Google Scholar] [CrossRef]
- Dégano, I.R.; Salomaa, V.; Veronesi, G.; Ferriéres, J.; Kirchberger, I.; Laks, T.; Havulinna, A.S.; Ruidavets, J.B.; Ferrario, M.M.; Meisinger, C.; et al. Twenty-five-year trends in myocardial infarction attack and mortality rates, and case-fatality, in six European populations. Heart 2015, 101, 1413–1421. [Google Scholar] [CrossRef]
- Roth, G.A.; Mensah, G.A.; Johnson, C.O.; Addolorato, G.; Ammirati, E.; Baddour, L.M.; Barengo, N.C.; Beaton, A.Z.; Benjamin, E.J.; Benziger, C.P.; et al. Global burden of cardiovascular diseases and risk factors, 1990–2019: Update from the GBD 2019 study. J. Am. Coll. Cardiol. 2020, 76, 2982–3021. [Google Scholar] [CrossRef]
- Collet, J.P.; Thiele, H.; Barbato, E.; Barthélémy, O.; Bauersachs, J.; Bhatt, D.L.; Dendale, P.; Dorobantu, M.; Edvardsen, T.; Folliguet, T.; et al. 2020 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur. Heart J. 2021, 42, 1289–1367. [Google Scholar] [CrossRef]
- Reed, G.W.; Rossi, J.E.; Cannon, C.P. Acute myocardial infarction. Lancet 2017, 389, 197–210. [Google Scholar] [CrossRef] [PubMed]
- Lawton, J.S.; Tamis-Holland, J.E.; Bangalore, S.; Bates, E.R.; Beckie, T.M.; Bischoff, J.M.; Bittl, J.A.; Cohen, M.G.; DiMaio, J.M.; Don, C.W. 2021 ACC/AHA/SCAI guideline for coronary artery revascularization: Executive summary: A report of the American College of Cardiology/American Heart Association joint committee on clinical practice guidelines. Circulation 2022, 145, e4–e17. [Google Scholar] [CrossRef]
- Reuter, H.; Jordan, J. Status of hypertension in Europe. Curr. Opin. Cardiol. 2019, 34, 342–349. [Google Scholar] [CrossRef]
- Kotseva, K.; De Backer, G.; De Bacquer, D.; Rydén, L.; Hoes, A.; Grobbee, D.; Maggioni, A.; Marques-Vidal, P.; Jennings, C.; Abreu, A.; et al. Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27 countries: Results from the European Society of Cardiology ESC-EORP EUROASPIRE V registry. Eur. J. Prev. Cardiol. 2019, 26, 824–835. [Google Scholar] [CrossRef]
- Barrios, V.; Soronen, J.; Carter, A.M.; Anastassopoulou, A. Lipid management across Europe in the real-world setting: A rapid evidence review. Curr. Med. Res. Opin. 2021, 37, 2049–2059. [Google Scholar] [CrossRef]
- WHO; European Region; European Health Information Gateway. Available online: https://gateway.euro.who.int/en/datasets/european-health-for-all-database/#mortality-based-indicators (accessed on 13 May 2025).
- State Data Agency. Available online: https://osp.stat.gov.lt/gyventojai1 (accessed on 6 February 2025).
- World Health Organization MONICA Project. MONICA Manual; World Health Organization MONICA Project: Geneva, Switzerland, 1990.
- Radisauskas, R.; Rastenyte, D.; Bernotiene, G.; Sopagiene, D.; Jancaityte, L. Morbidity and mortality from the major cardiovascular diseases in Kaunas population from 1983 to 2002. Med. Kaunas 2003, 39, 1208–1214. [Google Scholar]
- Lithuanian Hygiene Institute. 2025. Available online: https://www.hi.lt/sveikatos-informacijos-centras-mirties-atveju-ir-ju-priezasciu-stebesenos-skyrius/ (accessed on 16 January 2025).
- ICD-10 Codes. Available online: https://icd.who.int/browse10/2019/en#/IX (accessed on 20 February 2025).
- Ahmad, O.B.; Boschi-Pinto, C.; Lopez, A.D.; Murray, C.J.L.; Lozano, R.; Inoue, M. Age Standardization of Rates: A New WHO Standard; GPE Discussion Paper Series: No. 31. EIP/GPE/EBD; WHO: Geneva, Switzerland, 2001.
- Joinpoint Trend Analysis Software. Available online: https://surveillance.cancer.gov/joinpoint/ (accessed on 4 March 2025).
- Kim, H.J.; Fay, M.P.; Feuer, E.J.; Midthune, D.N. Permutation tests for joinpoint regression with applications to cancer rates. Stat. Med. 2000, 19, 335–351. [Google Scholar] [CrossRef]
- Tamosiunas, A.; Klumbiene, J.; Petkeviciene, J.; Radisauskas, R.; Vikhireva, O.; Luksiene, D.; Virviciute, D. Trends in major risk factors and mortality from main non-communicable diseases in Lithuania, 1985–2013. BMC Public Health 2016, 16, 717. [Google Scholar] [CrossRef] [PubMed]
- Kutkienė, S.; Petrulionienė, Ž.; Laucevičius, A.; Petrylaitė, M.; Maskeliūnaitė, D.; Puronaitė, R.; Kovaitė, M.; Kalibaitaitė, I.; Rinkūnienė, E.; Dženkevičiūtė, V.; et al. Severe dyslipidemia and concomitant risk factors in the middle-aged Lithuanian adults: A cross-sectional cohort study. Lipids Health Dis. 2018, 17, 88. [Google Scholar] [CrossRef]
- Radišauskas, R.; Lukšienė, D.; Krančiukaitė-Butylkinienė, D.; Šileikienė, L.; Tamošiūnas, A. The trends of arterial hypertension and ischemic heart disease in Lithuanian population (1983–2023). Eur. J. Public Health 2024, 34 (Suppl. S3), 559. [Google Scholar] [CrossRef]
- Laucevičius, A.; Rinkūnienė, E.; Petrulionienė, Ž.; Ryliškytė, L.; Jucevičienė, A.; Puronaitė, R.; Badarienė, J.; Navickas, R.; Mikolaitytė, J.; Gargalskaitė, U.; et al. Trends in cardiovascular risk factor prevalence among Lithuanian middle-aged adults between 2009 and 2018. Atherosclerosis 2020, 299, 9–14. [Google Scholar] [CrossRef] [PubMed]
- Rinkūnienė, E.; Petrulionienė, Ž.; Dženkevičiūtė, V.; Gimžauskaitė, S.; Mainelis, A.; Puronaitė, R.; Jucevičienė, A.; Gargalskaitė, U.; Laucevičius, A. Trends in cigarette smoking among middle-aged Lithuanian subjects participating in the primary prevention program between 2009 and 2016. Medicina 2019, 55, 130. [Google Scholar] [CrossRef] [PubMed]
- Radisauskas, R.; Kim, K.V.; Lange, S.; Liutkute-Gumarov, V.; Mesceriakova-Veliuliene, O.; Petkeviciene, J.; Stelemekas, M.; Telksnys, T.; Tran, A.; Rehm, J. Cardiovascular diseases mortality and alcohol control policy in Lithuania: Exploring a possible link. BMC Public Health 2021, 21, 2116. [Google Scholar] [CrossRef]
- Bovet, P.; Chiolero, A.; Paccaud, F.; Banatvala, N. Screening for cardiovascular disease risk and subsequent management in low and middle-income countries: Challenges and opportunities. Public Health Rev. 2015, 36, 13. [Google Scholar] [CrossRef]
- Mensah, G.A.; Wei, G.S.; Sorlie, P.D.; Fine, L.J.; Rosenberg, Y.; Kaufmann, P.G.; Mussolino, M.E.; Hsu, L.L.; Addou, E.; Engelgau, M.M.; et al. Decline in Cardiovascular Mortality: Possible Causes and Implications. Circ. Res. 2017, 120, 366–380. [Google Scholar] [CrossRef]
- Colpani, V.; Baena, C.P.; Jaspers, L.; van Dijk, G.M.; Farajzadegan, Z.; Dhana, K.; Tielemans, M.J.; Voortman, T.; Freak-Poli, R.; Veloso, G.G.; et al. Lifestyle factors, cardiovascular disease and all-cause mortality in middle-aged and elderly women: A systematic review and meta-analysis. Eur. J. Epidemiol. 2018, 33, 831–845. [Google Scholar] [CrossRef]
- Barauskas, M.; Unikas, R.; Žiubrytė, G. Outcomes of in-hospital treatment of cardiac patients who survived cardiac arrest and experienced coronary angiography. Arch. Med. Sci. Atheroscler. Dis. 2018, 3, e1–e7. [Google Scholar] [CrossRef]
- Mannsverk, J.; Wilsgaard, T.; Mathiesen, E.B.; Løchen, M.L.; Rasmussen, K.; Thelle, D.S.; Njølstad, I.; Hopstock, L.A.; Bønaa, K.H. Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population. Circulation 2016, 133, 74–81. [Google Scholar] [CrossRef] [PubMed]
- Mauri, L.; Kereiakes, D.J.; Yeh, R.W.; Driscoll-Shempp, P.; Cutlip, D.E.; Steg, P.G.; Normand, S.L.T.; Braunwald, E.; Wiviott, S.D.; Cohen, D.J.; et al. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N. Engl. J. Med. 2014, 371, 2155–2166. [Google Scholar] [CrossRef]
- SPRINT Research Group; Wright, J.T., Jr.; Williamson, J.D.; Whelton, P.K.; Snyder, J.K.; Sink, K.M.; Rocco, M.V.; Reboussin, D.M.; Rahman, M.; Oparil, S.; et al. A randomized trial of intensive versus standard blood-pressure control. N. Engl. J. Med. 2015, 373, 2103–2116. [Google Scholar]
- Grassi, G.; Cifkova, R.; Laurent, S.; Narkiewicz, K.; Redon, J.; Farsang, C.; Viigimaa, M.; Erdine, S.; Brambilla, G.; Bombelli, M.; et al. Blood pressure control and cardiovascular risk profile in hypertensive patients from central and eastern European countries: Results of the BP-CARE study. Eur. Heart J. 2011, 32, 218–225. [Google Scholar] [CrossRef] [PubMed]
- Pesce, G.; Marcon, A.; Calciano, L.; Perret, J.L.; Abramson, M.J.; Bono, R.; Bousquet, J.; Fois, A.G.; Janson, C.; Jarvis, D.; et al. Time and age trends in smoking cessation in Europe. PLoS ONE 2019, 14, e0211976. [Google Scholar] [CrossRef] [PubMed]
- Ray, K.K.; Haq, I.; Bilitou, A.; Manu, M.C.; Burden, A.; Aguiar, C.; Arca, M.; Connolly, D.L.; Eriksson, M.; Ferrières, J.; et al. Treatment gaps in the implementation of LDL cholesterol control among high- and very high-risk patients in Europe between 2020 and 2021: The multinational observational SANTORINI study. Lancet Reg. Health Eur. 2023, 29, 100624. [Google Scholar] [CrossRef]
- Vasile, V.C.; Jaffe, A.S. High-sensitivity cardiac troponin for the diagnosis of patients with acute coronary syndromes. Curr. Cardiol. Rep. 2017, 19, 92. [Google Scholar] [CrossRef] [PubMed]
- Pickering, J.W.; Than, M.P.; Cullen, L.; Aldous, S.; Ter Avest, E.; Body, R.; Carlton, E.W.; Collinson, P.; Dupuy, A.M.; Ekelund, U.; et al. Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Ann. Intern. Med. 2017, 166, 715–724. [Google Scholar] [CrossRef]
- Gasparri, C.; Curcio, A.; Torella, D.; Gaspari, M.; Celi, V.; Salituri, F.; Boncompagni, D.; Torella, M.; Gulletta, E.; Cuda, G.; et al. Proteomics reveals high levels of vitamin D binding protein in myocardial infarction. Front. Biosci. Elite Ed. 2010, 2, 796–804. [Google Scholar] [PubMed]
- Henry, T.D.; Tomey, M.I.; Tamis-Holland, J.E.; Thiele, H.; Rao, S.V.; Menon, V.; Klein, D.G.; Naka, Y.; Pina, I.L.; Kapur, N.K.; et al. Invasive management of acute myocardial infarction complicated by cardiogenic shock: A scientific statement from the American Heart Association. Circulation 2021, 143, e815–e829. [Google Scholar] [CrossRef]
- Marshall, D.C.; Al Omari, O.; Goodall, R.; Shalhoub, J.; Adcock, I.M.; Chung, K.F.; Salciccioli, J.D. Trends in prevalence, mortality, and disability-adjusted life-years relating to chronic obstructive pulmonary disease in Europe: An observational study of the global burden of disease database, 2001–2019. BMC Pulm. Med. 2022, 22, 289. [Google Scholar] [CrossRef]
- Cockwell, P.; Fisher, L.A. The global burden of chronic kidney disease. Lancet 2020, 395, 662–664. [Google Scholar] [CrossRef]
- Gooding, H.C.; Gidding, S.S.; Moran, A.E.; Redmond, N.; Allen, N.B.; Bacha, F.; Burns, T.L.; Catov, J.M.; Grandner, M.A.; Harris, K.M.; et al. Challenges and opportunities for the prevention and treatment of cardiovascular disease among young adults: Report from a national heart, lung, and blood institute working group. J. Am. Heart Assoc. 2020, 9, e016115. [Google Scholar] [CrossRef]
- Allen, N.; Wilkins, J.T. The urgent need to refocus cardiovascular disease prevention efforts on young adults. JAMA 2023, 329, 886–887. [Google Scholar] [CrossRef] [PubMed]
- Chieffo, A.; Hoye, A.; Mauri, F.; Mikhail, G.W.; Ammerer, M.; Grines, C.; Grinfeld, L.; Madan, M.; Presbitero, P.; Skelding, K.A.; et al. Gender-based issues in interventional cardiology: A consensus statement from the Women in Innovations (WIN) initiative. EuroIntervention 2010, 5, 773–779. [Google Scholar] [CrossRef] [PubMed]
- Sweeny, J.M.; Mehran, R. Gender outcomes in acute myocardial infarction: Are women from Venus and men from Mars? EuroIntervention 2011, 6, 1029–1031. [Google Scholar] [CrossRef]
- van Oortmerssen, J.A.E.; Ntlapo, N.; Tilly, M.J.; Bramer, W.M.; den Ruijter, H.M.; Boersma, E.; Kavousi, M.; Roeters van Lennep, J.E. Burden of risk factors in women and men with unrecognized myocardial infarction: A systematic review and meta-analysis. Cardiovasc. Res. 2024, 120, 1683–1692. [Google Scholar] [CrossRef]
- Špacírová, Z.; Kaptoge, S.; García-Mochón, L.; Rodríguez Barranco, M.; Sánchez Pérez, M.J.; Bondonno, N.P.; Tjønneland, A.; Weiderpass, E.; Grioni, S.; Espín, J.; et al. The cost-effectiveness of a uniform versus age-based threshold for one-off screening for prevention of cardiovascular disease. Eur. J. Health Econ. 2023, 24, 1033–1045. [Google Scholar] [CrossRef] [PubMed]
- Schmitz, T.; Meisinger, C.; Kirchberger, I.; Thilo, C.; Amann, U.; Baumeister, S.E.; Linseisen, J. Impact of COVID-19 pandemic lockdown on myocardial infarction care. Eur. J. Epidemiol. 2021, 36, 619–627. [Google Scholar] [CrossRef]
- Campo, G.; Fortuna, D.; Berti, E.; De Palma, R.; Pasquale, G.D.; Galvani, M.; Navazio, A.; Piovaccari, G.; Rubboli, A.; Guardigli, G.; et al. In- and out-of-hospital mortality for myocardial infarction during the first wave of the COVID-19 pandemic in Emilia-Romagna, Italy: A population-based observational study. Lancet Reg. Health Eur. 2021, 3, 100055. [Google Scholar] [CrossRef]
- Healthcare Expenditure Statistics–Overview. Available online: https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Healthcare_expenditure_statistics_-_overview (accessed on 18 March 2025).
- Nedkoff, L.; Lopez, D.; Hung, J.; Knuiman, M.; Briffa, T.G.; Murray, K.; Davis, E.; Aria, S.; Robinson, K.; Beilby, J.; et al. Validation of ICD-10-AM coding for myocardial infarction subtype in hospitalisation data. Heart Lung Circ. 2022, 31, 849–858. [Google Scholar] [CrossRef]
- Lloyd-Jones, D.M.; Martin, D.O.; Larson, M.G.; Levy, D. Accuracy of death certificates for coding coronary heart disease as the cause of death. Ann. Intern. Med. 1998, 129, 1020–1026. [Google Scholar] [CrossRef]
Years | Males | Females | ||
---|---|---|---|---|
25–54 | 55–64 | 25–54 | 55–64 | |
2000 | 223.39 | 1229.00 | 36.93 | 346.93 |
2001 | 172.46 | 1261.27 | 35.48 | 320.03 |
2002 | 216.48 | 1272.19 | 39.42 | 393.93 |
2003 | 260.85 | 1506.13 | 37.47 | 379.78 |
2004 | 208.27 | 1466.77 | 33.70 | 462.18 |
2005 | 226.66 | 1579.75 | 35.60 | 460.55 |
2006 | 215.10 | 1610.81 | 45.15 | 428.38 |
2007 | 233.96 | 1365.40 | 28.48 | 405.45 |
2008 | 198.12 | 1376.67 | 42.82 | 416.34 |
2009 | 182.97 | 1517.68 | 45.15 | 379.01 |
2010 | 215.69 | 1512.98 | 26.97 | 409.07 |
2011 | 199.34 | 1353.45 | 44.64 | 396.48 |
2012 | 181.55 | 1501.62 | 29.16 | 383.85 |
2013 | 189.57 | 1222.27 | 32.82 | 289.67 |
2014 | 166.35 | 1230.81 | 25.06 | 284.39 |
2015 | 169.19 | 1171.35 | 21.77 | 235.32 |
2016 | 178.20 | 1321.03 | 24.20 | 277.99 |
2017 | 232.60 | 1859.71 | 34.93 | 346.85 |
2018 | 184.31 | 1311.74 | 25.68 | 279.91 |
2019 | 152.79 | 1302.63 | 26.30 | 318.90 |
2020 | 177.35 | 1343.02 | 32.77 | 293.98 |
2021 | 99.46 | 983.15 | 20.10 | 167.92 |
2022 | 92.34 | 954.97 | 16.87 | 178.37 |
2023 | 115.58 | 1181.57 | 27.40 | 251.36 |
Average | 187.19 | 1351.50 | 32.04 | 337.78 |
AAPC 1 and p-value | −2.2%/yr., p < 0.001 | −0.7%/yr., p = 0.1 | −2.1%/yr., p = 0.002 | −2.4%/yr., p < 0.001 |
Age Groups | Sex | Joinpoints (Years) | Period 1 | Annual Percentage Change with 95% CI | Period 2 | Annual Percentage Change with 95% CI |
---|---|---|---|---|---|---|
25–64 | Males | 2017 | 2000–2017 | −0.2 (+0.9; −0.4) | 2017–2023 | −7.1 (−12.2; −1.7) * |
Females | 2006 | 2000–2006 | +3.7 (−2.2; 10.1) | 2006–2023 | −3.8 (−5.2; −2.4) * | |
25–54 | Males | 2018 | 2000–2018 | −1.1 (−2.3; +0.2) | 2018–2023 | −11.7 (−21.1; −1.0) * |
Females | 2009 | 2000–2009 | +0.6 (−3.7; +5.1) | 2009–2023 | −3.9 (−6.6; −1.0) * | |
55–64 | Males | 2017 | 2000–2017 | +0.3 (−0.8; +1.5) | 2017–2023 | −5.6 (−10.8; −0.2) * |
Females | 2005 | 2000–2005 | +6.9 (−1.5; +16.0) | 2005–2023 | −3.9 (−5.2; −2.6) * |
Years | Males | Females | ||
---|---|---|---|---|
25–54 | 55–64 | 25–54 | 55–64 | |
2000 | 52.34 | 402.51 | 4.86 | 87.69 |
2001 | 38.23 | 495.08 | 8.59 | 53.34 |
2002 | 39.61 | 414.20 | 6.39 | 70.49 |
2003 | 64.92 | 511.97 | 4.22 | 62.60 |
2004 | 63.30 | 494.96 | 3.13 | 118.72 |
2005 | 60.23 | 518.45 | 3.12 | 106.61 |
2006 | 63.16 | 598.65 | 9.59 | 77.11 |
2007 | 85.99 | 494.80 | 6.44 | 86.27 |
2008 | 55.45 | 452.52 | 7.73 | 48.21 |
2009 | 51.79 | 565.92 | 7.48 | 66.88 |
2010 | 47.49 | 508.67 | 2.06 | 80.04 |
2011 | 48.96 | 561.68 | 6.94 | 45.57 |
2012 | 39.67 | 541.13 | 4.44 | 103.87 |
2013 | 36.00 | 425.14 | 3.41 | 71.30 |
2014 | 28.84 | 466.41 | 3.54 | 61.25 |
2015 | 39.50 | 448.06 | 2.45 | 52.29 |
2016 | 48.68 | 417.17 | 3.77 | 91.22 |
2017 | 29.41 | 374.44 | 7.64 | 73.70 |
2018 | 43.21 | 344.87 | 12.84 | 51.68 |
2019 | 19.28 | 388.94 | 0.01 | 73.26 |
2020 | 44.61 | 433.43 | 5.78 | 77.82 |
2021 | 36.85 | 381.11 | 5.46 | 86.01 |
2022 | 17.29 | 383.10 | 4.16 | 74.67 |
2023 | 13.86 | 388.23 | 2.76 | 62.84 |
Average | 44.53 | 458.81 | 5.28 | 74.31 |
AAPC 1 and p-value | −3.3%/yr., p = 0.002 | −1.2%/yr., p = 0.005 | −0.4%/yr., p = 0.8 | −0.7%/yr., p = 0.4 |
Age Groups | Sex | Joinpoints (Years) | Period 1 | Annual Percentage Change with 95% CI | Period 2 | Annual Percentage Change with 95% CI |
---|---|---|---|---|---|---|
25–64 | Males | 2006 | 2000–2006 | +5.5 (+1.0; +10.3) * | 2006–2023 | −3.6 (−4.6; −2.6) * |
Females | 2004 | 2000–2004 | +2.9 (−12.4; 20.8) | 2004–2023 | −1.1 (−2.6; +0.4) | |
25–54 | Males | 2006 | 2000–2006 | +7.0 (−3.8; +19.0) | 2006–2023 | −5.8 (−8.4; −3.1) * |
Females | 2020 | 2000–2020 | +0.7 (−3.1; +4.7) | 2020–2023 | −23.5 (−68.8; +87.4) | |
55–64 | Males | 2006 | 2000–2006 | +4.7 (0.0; +9.6) * | 2006–2023 | −2.5 (−3.4; −1.5) * |
Females | 2004 | 2000–2004 | +5.1 (−14.6; +29.5) | 2004–2023 | −1.2 (−3.1; +0.7) |
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© 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Radisauskas, R.; Sileikiene, L.; Kranciukaite-Butylkiniene, D.; Augustis, S.; Jasukaitiene, E.; Luksiene, D.; Tamosiunas, A.; Marcinkeviciene, K.; Virviciute, D.; Zaliaduonyte, D.; et al. Trends in Myocardial Infarction Morbidity and Mortality from Ischemic Heart Disease in Middle-Aged Lithuanian Population from 2000 to 2023: Data from Population-Based Kaunas Ischemic Heart Disease Register. Medicina 2025, 61, 910. https://doi.org/10.3390/medicina61050910
Radisauskas R, Sileikiene L, Kranciukaite-Butylkiniene D, Augustis S, Jasukaitiene E, Luksiene D, Tamosiunas A, Marcinkeviciene K, Virviciute D, Zaliaduonyte D, et al. Trends in Myocardial Infarction Morbidity and Mortality from Ischemic Heart Disease in Middle-Aged Lithuanian Population from 2000 to 2023: Data from Population-Based Kaunas Ischemic Heart Disease Register. Medicina. 2025; 61(5):910. https://doi.org/10.3390/medicina61050910
Chicago/Turabian StyleRadisauskas, Ricardas, Lolita Sileikiene, Daina Kranciukaite-Butylkiniene, Sarunas Augustis, Erika Jasukaitiene, Dalia Luksiene, Abdonas Tamosiunas, Karolina Marcinkeviciene, Dalia Virviciute, Diana Zaliaduonyte, and et al. 2025. "Trends in Myocardial Infarction Morbidity and Mortality from Ischemic Heart Disease in Middle-Aged Lithuanian Population from 2000 to 2023: Data from Population-Based Kaunas Ischemic Heart Disease Register" Medicina 61, no. 5: 910. https://doi.org/10.3390/medicina61050910
APA StyleRadisauskas, R., Sileikiene, L., Kranciukaite-Butylkiniene, D., Augustis, S., Jasukaitiene, E., Luksiene, D., Tamosiunas, A., Marcinkeviciene, K., Virviciute, D., Zaliaduonyte, D., & Sakalyte, G. (2025). Trends in Myocardial Infarction Morbidity and Mortality from Ischemic Heart Disease in Middle-Aged Lithuanian Population from 2000 to 2023: Data from Population-Based Kaunas Ischemic Heart Disease Register. Medicina, 61(5), 910. https://doi.org/10.3390/medicina61050910