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Volume 61
Issue 12
10.3390/medicina61122142
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Osaka Prognostic Score Predicts In-Hospital and One-Year Mortality Following Transcatheter Aortic Valve Implantation

by
Murat Akdoğan
1,
Emine Cansu Yücel
1,
Alperen Taş
2,
Yusuf Bozkurt Şahin
1,
Çağatay Tunca
1,
Ahmet Kıvrak
3,
Kürşat Akbuğa
1,
Veysel Ozan Tanık
1,
Ali Sezgin
1 and
Bülent Özlek
4,*
1
Department of Cardiology, Ankara Etlik City Hospital, 06000 Ankara, Turkey
2
Department of Cardiology, Kırşehir Training and Research Hospital, 40080 Kırşehir, Turkey
3
Department of Cardiology, School of Medicine, Hacettepe University, 06000 Ankara, Turkey
4
Department of Cardiology, School of Medicine, Muğla Sıtkı Koçman University, 48999 Muğla, Turkey
*
Author to whom correspondence should be addressed.
Medicina 2025, 61(12), 2142; https://doi.org/10.3390/medicina61122142 (registering DOI)
Submission received: 26 October 2025 / Revised: 28 November 2025 / Accepted: 28 November 2025 / Published: 30 November 2025
(This article belongs to the Special Issue Aortic Valve Replacement Innovations and Outcomes)
Versions Notes

Abstract

Background and Objectives: Conventional risk models may not adequately capture key biological determinants of mortality following transcatheter aortic valve implantation (TAVI), such as inflammation, malnutrition, and immune dysfunction. The Osaka Prognostic Score (OPS), incorporating CRP, albumin, and lymphocyte count, may address this gap. We aimed to evaluate the prognostic value of OPS for predicting in-hospital and one-year all-cause mortality after TAVI. Materials and Methods: In this retrospective single-center cohort study, 244 patients who underwent transfemoral TAVI between December 2022 and January 2024 were analyzed. OPS was calculated at baseline (range: 0–3), and its prognostic value for in-hospital and one-year all-cause mortality was evaluated using multivariable Cox regression, ROC analysis, and restricted cubic spline (RCS) modeling. Results: In-hospital and one-year mortality rates were 11.5% and 21.7%, respectively. Higher OPS scores were significantly associated with mortality in both periods. OPS independently predicted in-hospital mortality (HR: 2.018; 95% CI: 1.632–2.521; p = 0.017) and one-year mortality (HR: 2.125; 95% CI: 1.300–3.473; p = 0.003). ROC analysis yielded AUC values of 0.776 and 0.859 for in-hospital and one-year mortality, respectively. Kaplan–Meier curves revealed significantly reduced survival in patients with higher OPS (log-rank p < 0.001), and RCS analysis demonstrated a significant nonlinear association between increasing OPS values and mortality risk (p < 0.001). Conclusions: OPS is a simple, cost-effective, and biologically relevant prognostic index that independently predicts both in-hospital and one-year mortality following TAVI. By integrating markers of inflammation, nutrition, and immune competence, OPS may offer additional value in risk stratification and support clinical decision-making in this high-risk population.
Keywords: all-cause mortality; inflammation; malnutrition; Osaka prognostic score; transcatheter aortic valve implantation all-cause mortality; inflammation; malnutrition; Osaka prognostic score; transcatheter aortic valve implantation

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MDPI and ACS Style

Akdoğan, M.; Yücel, E.C.; Taş, A.; Şahin, Y.B.; Tunca, Ç.; Kıvrak, A.; Akbuğa, K.; Tanık, V.O.; Sezgin, A.; Özlek, B. Osaka Prognostic Score Predicts In-Hospital and One-Year Mortality Following Transcatheter Aortic Valve Implantation. Medicina 2025, 61, 2142. https://doi.org/10.3390/medicina61122142

AMA Style

Akdoğan M, Yücel EC, Taş A, Şahin YB, Tunca Ç, Kıvrak A, Akbuğa K, Tanık VO, Sezgin A, Özlek B. Osaka Prognostic Score Predicts In-Hospital and One-Year Mortality Following Transcatheter Aortic Valve Implantation. Medicina. 2025; 61(12):2142. https://doi.org/10.3390/medicina61122142

Chicago/Turabian Style

Akdoğan, Murat, Emine Cansu Yücel, Alperen Taş, Yusuf Bozkurt Şahin, Çağatay Tunca, Ahmet Kıvrak, Kürşat Akbuğa, Veysel Ozan Tanık, Ali Sezgin, and Bülent Özlek. 2025. "Osaka Prognostic Score Predicts In-Hospital and One-Year Mortality Following Transcatheter Aortic Valve Implantation" Medicina 61, no. 12: 2142. https://doi.org/10.3390/medicina61122142

APA Style

Akdoğan, M., Yücel, E. C., Taş, A., Şahin, Y. B., Tunca, Ç., Kıvrak, A., Akbuğa, K., Tanık, V. O., Sezgin, A., & Özlek, B. (2025). Osaka Prognostic Score Predicts In-Hospital and One-Year Mortality Following Transcatheter Aortic Valve Implantation. Medicina, 61(12), 2142. https://doi.org/10.3390/medicina61122142

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