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Systematic Review

Efficacy of Topical Intervention for Recurrent Aphthous Stomatitis: A Network Meta-Analysis

by 1, 2, 3, 4,* and 4,*
1
College of Stomatology, Chongqing Medical University, Chongqing 400016, China
2
College of Nursing, Chongqing Medical University, Chongqing 400016, China
3
First Clinical College, Chongqing Medical University, Chongqing 400016, China
4
The Center of Experimental Teaching Management, Chongqing Medical University, Chongqing 400016, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Joseph Nissan and Gavriel Chaushu
Medicina 2022, 58(6), 771; https://doi.org/10.3390/medicina58060771
Received: 13 May 2022 / Revised: 1 June 2022 / Accepted: 2 June 2022 / Published: 7 June 2022
(This article belongs to the Topic State-of-the-Art Dentistry and Oral Health)
Background and objectives: To compare the efficacy and safety of topical interventions used for recurrent aphthous stomatitis. Materials and Methods: This network meta-analysis was conducted in accordance with the PRISMA statement. We searched four electronic databases, PubMed, Web of Science (WOS), Cochrane Central Register of Controlled Trials and Embase, for randomized controlled trials reporting efficacy and safety data on topical interventions for recurrent aphthous stomatitis. We performed a quality evaluation using a methodology based on the Cochrane Handbook. Two authors independently extracted data on healing effect, size reduction effect, symptom reduction effect, recurrence and safety assessment. Network meta-analysis was then performed using ADDIS and RevMan. Results: A total of 72 trials (5272 subjects) involving 29 topical interventions were included. Honey, lnsulin liposome gel, laser, amlexanox, glycyrrhiza and triamcinolone had better efficacy performance. Probiotics and chlorhexidine helped to prolong ulcer intervals and reduce recurrence. Doxycycline and penicillin had a high risk of adverse events. Hematologic evaluation showed no preference. The rank possibility of size-reducing effect and symptom-reducing effect supported the short-term effect of laser and the long-term effect of probiotics. Conclusions: We recommend the use of laser as a short-term intervention during the exacerbation phase of RAS and probiotics as a long-term intervention during the exacerbation and remission phases of RAS. View Full-Text
Keywords: recurrent aphthous stomatitis; network meta-analysis; topical intervention recurrent aphthous stomatitis; network meta-analysis; topical intervention
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MDPI and ACS Style

Liu, H.; Tan, L.; Fu, G.; Chen, L.; Tan, H. Efficacy of Topical Intervention for Recurrent Aphthous Stomatitis: A Network Meta-Analysis. Medicina 2022, 58, 771. https://doi.org/10.3390/medicina58060771

AMA Style

Liu H, Tan L, Fu G, Chen L, Tan H. Efficacy of Topical Intervention for Recurrent Aphthous Stomatitis: A Network Meta-Analysis. Medicina. 2022; 58(6):771. https://doi.org/10.3390/medicina58060771

Chicago/Turabian Style

Liu, Hao, Lei Tan, Gege Fu, Ling Chen, and Hua Tan. 2022. "Efficacy of Topical Intervention for Recurrent Aphthous Stomatitis: A Network Meta-Analysis" Medicina 58, no. 6: 771. https://doi.org/10.3390/medicina58060771

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