Neutrophil-to-Lymphocyte Ratio and Systemic Immune-Inflammation Index—Biomarkers in Interstitial Lung Disease
Abstract
:1. Introduction
2. Materials and Methods
3. Discussion
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
References
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Parameters | Idiopathic Pulmonary Fibrosis (n = 24) | Connective Tissue Disease Associated Interstitial Lung Disease (n = 18) | Control Group (n = 50) | p Value |
---|---|---|---|---|
Age (years) | 65.79 (±7.64) | 57.61 (±13.16) | 55.04 (±3.27) | 0.001 |
Male | 14 (58.3%) | 11 (61.1%) | 24 (48%) | 0.64 |
Female | 10 (41.7%) | 7 (38.9%) | 26 (52%) | |
Active smoker | 5 (20.8%) | 5 (27.8%) | 12 (24%) | 0.27 |
Ex-smoker | 6 (25%) | 0 (0%) | 5 (10%) | 0.13 |
Platelets | 221.45 (±60.12) | 246.83 (±93.41) | 250.98 (±49.36) | 0.16 |
SII 1 | 619.37 (±329.51) | 671.55 (±365.73) | 569.73 (±326.67) | 0.13 |
Neutrophils | 4.68 (±0.97) | 4.56 (±2.34) | 4.30 (±1.59) | 0.61 |
Lymphocytes | 1.85 (±0.59) | 1.71 (±0.68) | 2.36 (±0.77) | 0.001 |
NLR 2 | 2.84 (±1.24) | 2.80 (±1.08) | 2.00 (±1.05) | 0.003 |
Parametes | Idiopathic Pulmonary Fibrosis (n = 24) | Connective Tissue Disease-Associated Interstitial Lung Disease (n = 18) | p Value |
---|---|---|---|
Age (years) | 65.79 (±7.64) | 57.61 (±13.16) | 0.023 |
Male | 14 (58.3%) | 11 (61.1%) | 0.85 |
Female | 10 (41.7%) | 7 (38.9%) | |
Active smoker | 5 (20.8%) | 5 (27.8%) | 0.48 |
Ex-smoker | 6 (25%) | 0 (0%) | 0.02 |
Platelets | 221.45 (±60.12) | 246.83 (±93.41) | 0.29 |
SII 1 | 619.37 (±329.51) | 671.55 (±365.73) | 0.67 |
Neutrophis | 4.68 (±0.97) | 4.56 (±2.34) | 0.82 |
WBC 2 | 1.85 (±0.59) | 1.71 (±0.68) | 0.48 |
NLR 3 | 2.84 (±1.24) | 2.80 (±1.08) | 0.92 |
N | Mean | Std. Deviation | Std. Error | Interval for Mean | Minimum | Maximum | ||
---|---|---|---|---|---|---|---|---|
Lower Bound | Upper Bound | |||||||
IPF 2 | 18 | 3.0139 | 1.35215 | 0.31871 | 2.3415 | 3.6863 | 1.39 | 5.98 |
CTD-ILD 3 | 18 | 2.8067 | 1.08980 | 0.25687 | 2.2647 | 3.3486 | 1.57 | 5.24 |
IPF Death | 6 | 2.3217 | 0.65755 | 0.26845 | 1.6316 | 3.0117 | 1.65 | 3.31 |
Total | 42 | 2.8262 | 1.16454 | 0.17969 | 2.4633 | 3.1891 | 1.39 | 5.98 |
N | Mean | Std. Deviation | Std. Error | Interval for Mean | Minimum | Maximum | ||
---|---|---|---|---|---|---|---|---|
Lower Bound | Upper Bound | |||||||
IPF 2 | 18 | 645.8889 | 354.55322 | 83.56900 | 469.5737 | 822.2041 | 300.00 | 1643.00 |
NSIP 3 | 18 | 671.5556 | 365.73475 | 86.20451 | 489.6799 | 853.4312 | 351.00 | 1762.00 |
IPF Death | 6 | 539.8333 | 248.88826 | 101.60821 | 278.6411 | 801.0255 | 308.00 | 1005.00 |
Total | 42 | 641.7381 | 342.13591 | 52.79727 | 535.1210 | 748.3551 | 300.00 | 1762.00 |
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Ruta, V.M.; Man, A.M.; Alexescu, T.G.; Motoc, N.S.; Tarmure, S.; Ungur, R.A.; Todea, D.A.; Coste, S.C.; Valean, D.; Pop, M.C. Neutrophil-to-Lymphocyte Ratio and Systemic Immune-Inflammation Index—Biomarkers in Interstitial Lung Disease. Medicina 2020, 56, 381. https://doi.org/10.3390/medicina56080381
Ruta VM, Man AM, Alexescu TG, Motoc NS, Tarmure S, Ungur RA, Todea DA, Coste SC, Valean D, Pop MC. Neutrophil-to-Lymphocyte Ratio and Systemic Immune-Inflammation Index—Biomarkers in Interstitial Lung Disease. Medicina. 2020; 56(8):381. https://doi.org/10.3390/medicina56080381
Chicago/Turabian StyleRuta, Victoria Maria, Adina Milena Man, Teodora Gabriela Alexescu, Nicoleta Stefania Motoc, Simina Tarmure, Rodica Ana Ungur, Doina Adina Todea, Sorina Cezara Coste, Dan Valean, and Monica Carmen Pop. 2020. "Neutrophil-to-Lymphocyte Ratio and Systemic Immune-Inflammation Index—Biomarkers in Interstitial Lung Disease" Medicina 56, no. 8: 381. https://doi.org/10.3390/medicina56080381