An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Thiol/Disulphide Homeostasis Parameters
2.2. Statistical Analyses
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Data | Control (n = 35) | Graves (n = 33) | p-Values |
---|---|---|---|
Age (Years) | 33.09 ± 10.65 | 31.94 ± 10.28 | =0.653 |
Gender (male), n (%) | 12 (34.3) | 15 (45.5) | =0.885 |
BMI (kg/m2) | 24.16 ± 1.65 | 24.76 ± 2.39 | =0.232 |
Albumin (g/L) | 4.93 ± 0.51 | 4.79 ± 0.36 | =0.192 |
TSH (µU/mL) | 1.94 ± 1.04 | 0.03 ± 0.07 | <0.001 |
FT3 (pg/dL) | 3.06 ± 0.33 | 8.51 ± 4.79 | <0.001 |
FT4 (ng/dL) | 1.01 ± 0.13 | 2.61 ± 1.33 | <0.001 |
Data | Control (n = 35) | Graves (n = 33) | p-Values |
---|---|---|---|
Native thiol (mmol/L) | 454.95 ± 57.89 | 397.42 ± 51.26 | <0.001 |
Total thiol (mmol/L) | 489.79 ± 58.05 | 439.47 ± 42.02 | <0.001 |
Disulphide (mmol/L) | 17.42 ± 6.67 | 21.03 ± 9.10 | 0.066 |
Disulphide/Native thiol (%) | 3.92 ± 1.62 | 5.56 ± 2.81 | 0.004 |
Disulphide/Total thiol (%) | 3.59 ± 1.38 | 4.89 ± 2.28 | 0.006 |
Native thiol/Total thiol (%) | 92.82 ± 2.77 | 90.22 ± 4.56 | 0.006 |
TAS (mmol TroloxEqv/L) | 0.60 ± 0.15 | 0.55 ± 0.15 | 0,198 |
TOS (µmol H2O2 Eqv/L) | 1.95 ± 0.44 | 2.40 ± 0.34 | <0.001 |
OSI (Arbitrary Unite) | 3.47 ± 1.27 | 4.65 ± 1.46 | 0.001 |
PC (nmol/mg protein) | 2.09 ± 0.49 | 2.52 ± 0.56 | 0.001 |
8-OHdG (ng/mL) | 24.52 ± 3.35 | 23.66 ± 3.21 | 0.282 |
Native Thiol | Total Thiol | Disulphide | Disulphide/Native Thiol | Disulphide/Total Thiol | Native Thiol/Total Thiol | PC | 8OHdG | TAS | TOS | OSI | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|
FT3 | r | −0.543 | −0.505 | 0.364 | 0.481 | 0.464 | −0.464 | 0.700 | 0.267 | −0.286 | 0.512 | 0.569 |
p | 0.001 | 0.003 | 0.037 | 0.005 | 0.006 | 0.006 | <0.001 | 0.134 | 0.106 | 0.002 | 0.001 | |
FT4 | r | −0.562 | −0.493 | 0.445 | 0.525 | 0.518 | −0.518 | 0.553 | 0.217 | −0.201 | 0.376 | 0.441 |
p | 0.001 | 0.004 | 0.010 | 0.002 | 0.002 | 0.002 | 0.001 | 0.225 | 0.262 | 0.031 | 0.010 |
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Agan, V.; Celik, H.; Eren, M.A.; Agan, F.Z.; Erel, O.; Neselioglu, S.; Koyuncu, I.; Gonel, A. An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease. Medicina 2019, 55, 275. https://doi.org/10.3390/medicina55060275
Agan V, Celik H, Eren MA, Agan FZ, Erel O, Neselioglu S, Koyuncu I, Gonel A. An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease. Medicina. 2019; 55(6):275. https://doi.org/10.3390/medicina55060275
Chicago/Turabian StyleAgan, Veysel, Hakim Celik, Mehmet Ali Eren, Fatma Zehra Agan, Ozcan Erel, Salim Neselioglu, Ismail Koyuncu, and Ataman Gonel. 2019. "An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease" Medicina 55, no. 6: 275. https://doi.org/10.3390/medicina55060275