Pepsinogen testing for evaluation of the success of Helicobacter pylori eradication at 4 weeks after completion of therapy
Abstract
Material and methods: Altogether 42 patients (25 women, 17 men), mean age 45 years (range 23–74), were enrolled. Pepsinogens I and II, gastrin-17 and H. pylori IgG antibodies were measured in plasma samples using an ELISA test (Biohit, Oyj., Finland) before the eradication and 4 weeks after completing the treatment. The success of eradication was determined by a urea breath test.
Results: Eradication was successful in 31 patients (74%) and unsuccessful in 11 patients (26%). Pepsinogen II decreased significantly in both the successful (P = 0.029) and unsuccessful (P = 0.042) eradication groups. Pepsinogen I decreased significantly in the successful (P = 0.025) but not the unsuccessful (P = 0.29) eradication group. The pepsinogen I/II ratio increased in the successful eradication group (P = 0.0018) but not in the group in which treatment failed (P = 0.12). There were no differences in gastrin-17 or H. pylori antibody values.
Conclusions: A decrease in pepsinogen II levels cannot be used as a reliable marker for the successful eradication of H. pylori 4 weeks after the completion of treatment. The increase in pepsinogen I/II ratio reflects differences in pepsinogen production following the eradication irrespective of improvement in atrophy.
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Leja, M.; Lapina, S.; Polaka, I.; Rudzite, D.; Vilkoite, I.; Daugule, I.; Belkovets, A.; Pimanov, S.; Makarenko, J.; Tolmanis, I.; et al. Pepsinogen testing for evaluation of the success of Helicobacter pylori eradication at 4 weeks after completion of therapy. Medicina 2014, 50, 8-13. https://doi.org/10.1016/j.medici.2014.05.001
Leja M, Lapina S, Polaka I, Rudzite D, Vilkoite I, Daugule I, Belkovets A, Pimanov S, Makarenko J, Tolmanis I, et al. Pepsinogen testing for evaluation of the success of Helicobacter pylori eradication at 4 weeks after completion of therapy. Medicina. 2014; 50(1):8-13. https://doi.org/10.1016/j.medici.2014.05.001
Chicago/Turabian StyleLeja, Marcis, Sanita Lapina, Inese Polaka, Dace Rudzite, Ilona Vilkoite, Ilva Daugule, Anna Belkovets, Sergey Pimanov, Jelena Makarenko, Ivars Tolmanis, and et al. 2014. "Pepsinogen testing for evaluation of the success of Helicobacter pylori eradication at 4 weeks after completion of therapy" Medicina 50, no. 1: 8-13. https://doi.org/10.1016/j.medici.2014.05.001