Magnetic Resonance Study on Fractional Anisotropy and Neuronal Metabolite Ratios in Peritumoral Area of Cerebral Gliomas
Abstract
Material and Methods. Forty-five patients with histologically verified brain gliomas underwent diffusion tensor imaging (DTI) and MR spectroscopy (MRS). Metabolic ratios were calculated from choline (Cho), creatine (Cr), N-acetylaspartate (NAA), lactate/lipids (LL), myo-inositol (MI) spectroscopic values obtained within the tumor center, perifocal edema, and distant and contralateral normal-appearing white matter. DTI maps of FA were calculated at the same locations.
Results. A significant gradual increase of FA and a decrease of LL/Cr ratios from the tumor center to the normal-appearing white matter were observed. The Cho/Cr ratio was significantly lower in the distant normal-appearing white matter than in the perifocal edema and the tumor center. The NAA/Cr ratio was significantly reduced in the tumor center, perifocal edema, and distant normal-appearing white matter compared with the contralateral hemisphere. MRS and DTI measurements of glioma and peritumoral area had a high degree of repeatability.
Conclusions. Our study shows that MRS and DTI measurements are reproducible. The combined use of Cho/Cr, LL/Cr, and FA measurements is a promising MR technique that provides valuable additional information about the location of glioma potential border.
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Bieza, A.; Krumina, G. Magnetic Resonance Study on Fractional Anisotropy and Neuronal Metabolite Ratios in Peritumoral Area of Cerebral Gliomas. Medicina 2012, 48, 73. https://doi.org/10.3390/medicina48100073
Bieza A, Krumina G. Magnetic Resonance Study on Fractional Anisotropy and Neuronal Metabolite Ratios in Peritumoral Area of Cerebral Gliomas. Medicina. 2012; 48(10):73. https://doi.org/10.3390/medicina48100073
Chicago/Turabian StyleBieza, Anvita, and Gaida Krumina. 2012. "Magnetic Resonance Study on Fractional Anisotropy and Neuronal Metabolite Ratios in Peritumoral Area of Cerebral Gliomas" Medicina 48, no. 10: 73. https://doi.org/10.3390/medicina48100073