Comparison of C-reactive Protein Levels in Patients with Lung Cancer and Chronic Obstructive Pulmonary Disease
Abstract
Materials and Methods. In total, 140 persons were included in the study: 43 patients with lung cancer, 34 patients with lung cancer and COPD, 42 patients with COPD, and 21 healthy subjects. CRP analysis was performed with a serum protein analyzer using commercially available highsensitivity reagent kits.
Results. The C-reactive protein levels were significantly higher in the lung cancer patients with or without COPD compared with the COPD patients or the control group (20.42±1.95 and 22.49±2.31 vs. 8.37±0.91 and 2.49±0.47 mg/L, respectively; P<0.01). The patients with advanced lung cancer had higher CRP levels compared with the patients suffering from early stage lung cancer (23.11±1.72 vs. 14.59±2.23 mg/L, P<0.01). The CRP levels were significantly higher in the patients with early stage lung cancer compared with the COPD patients (14.59±2.23 mg/L vs. 8.37±0.91 mg/L, P<0.05). No association was found between CRP and histology, lung function, and smoking status in the patients with lung cancer.
Conclusions. Chronic inflammation plays an important role in both diseases: lung cancer and COPD. However, it seems that inflammation is more pronounced in patients with lung cancer, as the CRP levels were significantly higher in these patients than other groups.
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Vagulienė, N.; Žemaitis, M.; Miliauskas, S.; Urbonienė, D.; Brigita; Sakalauskas, R. Comparison of C-reactive Protein Levels in Patients with Lung Cancer and Chronic Obstructive Pulmonary Disease. Medicina 2011, 47, 421. https://doi.org/10.3390/medicina47080059
Vagulienė N, Žemaitis M, Miliauskas S, Urbonienė D, Brigita, Sakalauskas R. Comparison of C-reactive Protein Levels in Patients with Lung Cancer and Chronic Obstructive Pulmonary Disease. Medicina. 2011; 47(8):421. https://doi.org/10.3390/medicina47080059
Chicago/Turabian StyleVagulienė, Neringa, Marius Žemaitis, Skaidrius Miliauskas, Daiva Urbonienė, Brigita, and Raimundas Sakalauskas. 2011. "Comparison of C-reactive Protein Levels in Patients with Lung Cancer and Chronic Obstructive Pulmonary Disease" Medicina 47, no. 8: 421. https://doi.org/10.3390/medicina47080059
APA StyleVagulienė, N., Žemaitis, M., Miliauskas, S., Urbonienė, D., Brigita, & Sakalauskas, R. (2011). Comparison of C-reactive Protein Levels in Patients with Lung Cancer and Chronic Obstructive Pulmonary Disease. Medicina, 47(8), 421. https://doi.org/10.3390/medicina47080059