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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
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Immune factors in human embryo culture and their significance

Živilė Čerkienė
Audronė Eidukaitė
1 and
Audronė Usonienė
Institute of Immunology, Vilnius University
Vaisingumo klinika, ” Vilnius, Lithuania
Author to whom correspondence should be addressed.
Medicina 2010, 46(4), 233;
Submission received: 15 October 2008 / Accepted: 6 April 2010 / Published: 11 April 2010


There is increasing evidence that human development before implantation is regulated by embryonically and maternally derived growth factors. The “regulators” of embryonic origin such as soluble human leukocyte antigen G, platelet-activating factor, Th1/Th2 cytokines, insulinlike growth factor, epidermal growth factor, transforming growth factor α, colony-stimulating factor, platelet-derived growth factor may be used as indicators of embryo viability and implantation potential. The data prove the infl uence of growth factors on the development and growth of preimplantation embryos. Though there is a lot of research in the field of biomarkers during folliculogenesis and maternal-fetal interface, only few of them deal with regulators derived from embryonic cells to the cultivation medium. The aim of our study was to summarize the research dealing with immune markers produced by embryos in vitro and to estimate their impact on the cell growth, viability and implantation potential.
Keywords: immune factors; embryo; in vitro fertilization immune factors; embryo; in vitro fertilization

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MDPI and ACS Style

Čerkienė, Ž.; Eidukaitė, A.; Usonienė, A. Immune factors in human embryo culture and their significance. Medicina 2010, 46, 233.

AMA Style

Čerkienė Ž, Eidukaitė A, Usonienė A. Immune factors in human embryo culture and their significance. Medicina. 2010; 46(4):233.

Chicago/Turabian Style

Čerkienė, Živilė, Audronė Eidukaitė, and Audronė Usonienė. 2010. "Immune factors in human embryo culture and their significance" Medicina 46, no. 4: 233.

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