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Radiofrequency ablation of liver tumors (II): clinical application and outcomes

Tomas Vanagas
Antanas Gulbinas
Juozas Pundzius
1 and
Giedrius Barauskas
Department of Surgery, Kaunas University of Medicine
Institute for Biomedical Research, Kaunas University of Medicine, Lithuania
Author to whom correspondence should be addressed.
Medicina 2010, 46(2), 81;
Submission received: 26 March 2009 / Accepted: 5 February 2010 / Published: 10 February 2010


Radiofrequency ablation is one of the alternatives in the management of liver tumors, especially in patients who are not candidates for surgery. The aim of this article is to review applicability of radiofrequency ablation achieving complete tumor destruction, utility of imaging techniques for patients’ follow-up, indications for local ablative procedures, procedureassociated morbidity and mortality, and long-term results in patients with different tumors. The success of local thermal ablation consists in creating adequate volumes of tissue destruction with adequate “clear margin,” depending on improved delivery of radiofrequency energy and modulated tissue biophysiology. Different volumes of coagulation necrosis are achieved applying different types of electrodes, pulsing energy sources, utilizing sophisticated ablation schemes. Some additional methods are used to increase the overall deposition of energy through alterations in tissue electrical conductivity, to improve heat retention within the tissue, and to modulate tolerance of tumor tissue to hyperthermia. Contrast-enhanced computed tomography, magnetic resonance imaging, ultrasound or positron emission tomography are applied to control the effectiveness of radiofrequency ablation. The long-term results of radiofrequency ablation are controversial.
Keywords: radiofrequency ablation; liver tumor; outcomes radiofrequency ablation; liver tumor; outcomes

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MDPI and ACS Style

Vanagas, T.; Gulbinas, A.; Pundzius, J.; Barauskas, G. Radiofrequency ablation of liver tumors (II): clinical application and outcomes. Medicina 2010, 46, 81.

AMA Style

Vanagas T, Gulbinas A, Pundzius J, Barauskas G. Radiofrequency ablation of liver tumors (II): clinical application and outcomes. Medicina. 2010; 46(2):81.

Chicago/Turabian Style

Vanagas, Tomas, Antanas Gulbinas, Juozas Pundzius, and Giedrius Barauskas. 2010. "Radiofrequency ablation of liver tumors (II): clinical application and outcomes" Medicina 46, no. 2: 81.

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