Evaluation of pituitary imaging in patients with PROP-1 gene mutation
by
Natalija Tkačenko
1,*, 
Danutė Lašienė
2,
Silvija Jakštienė
3,
Algidas Basevičius
3 and
Rasa Verkauskienė
1 1
Department of Endocrinology
2
Institute of Endocrinology
3
Department of Radiology,
*
Author to whom correspondence should be addressed.
Medicina 2009, 45(9), 693; https://doi.org/10.3390/medicina45090090
Submission received: 20 May 2008
/
Accepted: 4 September 2009
/
Published: 9 September 2009
Abstract
The most common genetically determined cause of multiple pituitary hormone deficiency is PROP-1 gene mutation. PROP-1 is a transcription factor involved in the development of pituitary gland and affects hormonal synthesis of anterior pituitary.
The aim of our study was to evaluate radiological aspects of the pituitary region in patients with PROP-1 gene mutation. Pituitary imaging studies were performed in 12 patients with a confirmed PROP-1 gene mutation. Pituitary hyperplasia was found in 5 (42%) and pituitary hypoplasia in 4 (33%) patients. Changes in pituitary size were not associated with the type of PROP-1 gene mutation.
The aim of our study was to evaluate radiological aspects of the pituitary region in patients with PROP-1 gene mutation. Pituitary imaging studies were performed in 12 patients with a confirmed PROP-1 gene mutation. Pituitary hyperplasia was found in 5 (42%) and pituitary hypoplasia in 4 (33%) patients. Changes in pituitary size were not associated with the type of PROP-1 gene mutation.
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MDPI and ACS Style
Tkačenko, N.; Lašienė, D.; Jakštienė, S.; Basevičius, A.; Verkauskienė, R. Evaluation of pituitary imaging in patients with PROP-1 gene mutation. Medicina 2009, 45, 693. https://doi.org/10.3390/medicina45090090
AMA Style
Tkačenko N, Lašienė D, Jakštienė S, Basevičius A, Verkauskienė R. Evaluation of pituitary imaging in patients with PROP-1 gene mutation. Medicina. 2009; 45(9):693. https://doi.org/10.3390/medicina45090090
Chicago/Turabian StyleTkačenko, Natalija, Danutė Lašienė, Silvija Jakštienė, Algidas Basevičius, and Rasa Verkauskienė. 2009. "Evaluation of pituitary imaging in patients with PROP-1 gene mutation" Medicina 45, no. 9: 693. https://doi.org/10.3390/medicina45090090
