C-reactive protein levels in patients with chronic obstructive pulmonary disease and asthma
Abstract
Material and methods. We investigated 87 persons: 41 with COPD, 30 with asthma, and 16 controls. Clinical evaluation, pulmonary function tests, C-reactive protein concentration measurement, body mass index and smoking history evaluation were performed.
Results. We determined significantly higher C-reactive protein concentrations in COPD patients compared with asthma patients and controls (8.37±1.14 vs 3.14±0.67 and 2.39±0.59 mg/L, respectively; P<0.001). Creactive protein concentrations in smokers and ex-smokers with COPD were significantly higher than in COPD non-smokers (8.38±1.52 and 10.4±2.22 vs 4.10±0.86 mg/L, respectively; P<0.05). In COPD patients, C-reactive protein level correlated with FEV1 (R=–0.463, P=0.002), FEV1/FVC (R=–0.449, P=0.003), and pack-years (R=0.572, P=0.001). There was no correlation between C-reactive protein level and analyzed parameters in asthmatics and control group.
Conclusions. Our data support the hypothesis that systemic inflammation plays a role in the pathogenesis of COPD, and cigarette smoking might influence this inflammation.
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Urbonienė, D.; Sakalauskas, R.; Šitkauskienė, B. C-reactive protein levels in patients with chronic obstructive pulmonary disease and asthma. Medicina 2008, 44, 833. https://doi.org/10.3390/medicina44110105
Urbonienė D, Sakalauskas R, Šitkauskienė B. C-reactive protein levels in patients with chronic obstructive pulmonary disease and asthma. Medicina. 2008; 44(11):833. https://doi.org/10.3390/medicina44110105
Chicago/Turabian StyleUrbonienė, Daiva, Raimundas Sakalauskas, and Brigita Šitkauskienė. 2008. "C-reactive protein levels in patients with chronic obstructive pulmonary disease and asthma" Medicina 44, no. 11: 833. https://doi.org/10.3390/medicina44110105