Evaluation of a novel 14C-urea breath test “Heliprobe” in diagnosis of Helicobacter pylori infection
Department of Gastroenterology, Kaunas University of Medicine, Lithuania
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Author to whom correspondence should be addressed.
Medicina 2007, 43(1), 32; https://doi.org/10.3390/medicina43010004
Submission received: 20 March 2006
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Accepted: 18 December 2006
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Published: 23 December 2006
Abstract
Background. At present, 14C-urea breath test is considered a gold standard for diagnosis of Helicobacter pylori infection, but they are time-consuming, comparably expensive, and usually not portable tests. The aim of our study was to establish the diagnostic value of the novel, inexpensive, quick, and convenient to use 14C-urea breath test “Heliprobe”, Noster AB, Sweden.
Material and methods. Helicobacter pylori testing using “Heliprobe” was performed in 108 consecutive patients. Helicobacter pylori was also investigated using rapid urease test and Giemsa stained histological specimens according to Sydney system.
Results. The diagnostic values of “Heliprobe” assuming the Helicobacter pylori positivity, if the results of two tests (rapid urease test and histology) are positive, were: sensitivity – 97%, specificity – 87%, positive predictive value – 93%, negative predictive value – 95%, accuracy – 94%. The diagnostic values of “Heliprobe” assuming the Helicobacter pylori positivity, if at least the results of one test are positive: sensitivity – 92%, specificity – 100%, positive predictive value – 100%, negative predictive value – 84%, accuracy – 94%.
Conclusions. The novel, quick, convenient to use 14C-urea breath test “Heliprobe” is accurate, reliable, and useful for the diagnosis of Helicobacter pylori infection in routine clinical practice
Material and methods. Helicobacter pylori testing using “Heliprobe” was performed in 108 consecutive patients. Helicobacter pylori was also investigated using rapid urease test and Giemsa stained histological specimens according to Sydney system.
Results. The diagnostic values of “Heliprobe” assuming the Helicobacter pylori positivity, if the results of two tests (rapid urease test and histology) are positive, were: sensitivity – 97%, specificity – 87%, positive predictive value – 93%, negative predictive value – 95%, accuracy – 94%. The diagnostic values of “Heliprobe” assuming the Helicobacter pylori positivity, if at least the results of one test are positive: sensitivity – 92%, specificity – 100%, positive predictive value – 100%, negative predictive value – 84%, accuracy – 94%.
Conclusions. The novel, quick, convenient to use 14C-urea breath test “Heliprobe” is accurate, reliable, and useful for the diagnosis of Helicobacter pylori infection in routine clinical practice
Keywords:
Helicobacter pylori; 14C-urea breath test
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MDPI and ACS Style
Jonaitis, L.V.; Kiudelis, G.; Kupčinskas, L. Evaluation of a novel 14C-urea breath test “Heliprobe” in diagnosis of Helicobacter pylori infection. Medicina 2007, 43, 32. https://doi.org/10.3390/medicina43010004
AMA Style
Jonaitis LV, Kiudelis G, Kupčinskas L. Evaluation of a novel 14C-urea breath test “Heliprobe” in diagnosis of Helicobacter pylori infection. Medicina. 2007; 43(1):32. https://doi.org/10.3390/medicina43010004
Chicago/Turabian StyleJonaitis, Laimas Virginijus, Gediminas Kiudelis, and Limas Kupčinskas. 2007. "Evaluation of a novel 14C-urea breath test “Heliprobe” in diagnosis of Helicobacter pylori infection" Medicina 43, no. 1: 32. https://doi.org/10.3390/medicina43010004
