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Volume 47
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10.3390/cimb47080619
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

The Extract of Periplaneta americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota

by
Tangfei Guan
1,2,3,
Xin Yang
1,2,
Canhui Hong
1,2,
Zehao Zhang
3,
Peiyun Xiao
1,2,
Yongshou Yang
1,2,
Chenggui Zhang
1,2 and
Zhengchun He
1,2,*
1
Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali 671000, China
2
National-Local Joint Engineering Research Center of Entomoceutics, Dali 671000, China
3
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2025, 47(8), 619; https://doi.org/10.3390/cimb47080619 (registering DOI)
Submission received: 11 June 2025 / Revised: 19 July 2025 / Accepted: 29 July 2025 / Published: 4 August 2025
(This article belongs to the Special Issue Pathogenesis, Diagnosis and Treatment of Skin and Sexually Transmitted Diseases)
Review Reports Versions Notes

Abstract

Alopecia, a prevalent dermatological disorder affecting over half of the global population, is strongly associated with psychological distress. Extracts from Periplaneta americana (L. PA), a medicinal insect resource, exhibit pharmacological activities (e.g., antioxidant, anti-inflammatory, microcirculation improvement) that align with core therapeutic targets for alopecia. This study aimed to systematically investigate the efficacy and mechanisms of PA extracts in promoting hair regeneration. A strategy combining network pharmacology prediction and in vivo experiments was adopted. The efficacy of a Periplaneta americana extract was validated by evaluating hair regrowth status and skin pathological staining in C57BL/6J mice. Transcriptomics, metabolomics, RT-qPCR, and 16s rRNA techniques were integrated to dissect the underlying mechanisms of its hair-growth-promoting effects. PA-011 significantly promoted hair regeneration in depilated mice via multiple mechanisms: enhanced skin superoxide dismutase activity and upregulated vascular endothelial growth factor expression; modulated FOXO/PI3K/AKT signaling pathway and restored skin microbiota homeostasis; and accelerated transition of hair follicles from the telogen to anagen phase. PA-011 exerts hair-promoting effects through synergistic modulation of FOXO/PI3K/AKT signaling and the skin microbiome. As a novel therapeutic candidate, it warrants further systematic investigation for clinical translation.
Keywords: alopecia; Periplaneta americana (L.); network pharmacology; transcriptomics; metabolomics; skin microbiota alopecia; Periplaneta americana (L.); network pharmacology; transcriptomics; metabolomics; skin microbiota

Share and Cite

MDPI and ACS Style

Guan, T.; Yang, X.; Hong, C.; Zhang, Z.; Xiao, P.; Yang, Y.; Zhang, C.; He, Z. The Extract of Periplaneta americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota. Curr. Issues Mol. Biol. 2025, 47, 619. https://doi.org/10.3390/cimb47080619

AMA Style

Guan T, Yang X, Hong C, Zhang Z, Xiao P, Yang Y, Zhang C, He Z. The Extract of Periplaneta americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota. Current Issues in Molecular Biology. 2025; 47(8):619. https://doi.org/10.3390/cimb47080619

Chicago/Turabian Style

Guan, Tangfei, Xin Yang, Canhui Hong, Zehao Zhang, Peiyun Xiao, Yongshou Yang, Chenggui Zhang, and Zhengchun He. 2025. "The Extract of Periplaneta americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota" Current Issues in Molecular Biology 47, no. 8: 619. https://doi.org/10.3390/cimb47080619

APA Style

Guan, T., Yang, X., Hong, C., Zhang, Z., Xiao, P., Yang, Y., Zhang, C., & He, Z. (2025). The Extract of Periplaneta americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota. Current Issues in Molecular Biology, 47(8), 619. https://doi.org/10.3390/cimb47080619

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