Next Article in Journal
The Complex Role of MAPK/ERK Signaling Pathway in Different Types of Thrombocytopenia
Previous Article in Journal
In Silico Characterization of ADAR1: Structure, Dynamics, and Functional Implications
Previous Article in Special Issue
Competition for Chaperones: A Trade-Off Between Thermotolerance and Antiviral Immunity in Plants
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
CIMB
Volume 47
Issue 11
10.3390/cimb47110959
cimb-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Environmental Stressors and Neuroinflammation: Linking Climate Change to Alzheimer’s Disease

by
Mario Caldarelli
1,2,†,
Pierluigi Rio
1,2,†,
Antonio Gasbarrini
1,2,
Giovanni Gambassi
1,2 and
Rossella Cianci
1,2,*
1
Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, 00168 Rome, Italy
2
Fondazione Policlinico Universitario A. Gemelli, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), 00168 Rome, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2025, 47(11), 959; https://doi.org/10.3390/cimb47110959 (registering DOI)
Submission received: 19 October 2025 / Revised: 13 November 2025 / Accepted: 17 November 2025 / Published: 18 November 2025
(This article belongs to the Special Issue Latest Review Papers in Molecular Biology 2025)
Review Reports Versions Notes

Abstract

Environmental exposures are widely recognized as major risk factors for human health. According to projections by the World Health Organization, climate change is expected to cause a significant increase in mortality within the next few decades. Environmental factors, including diet, weather, occupational exposures, and pollutants play a key role in human diseases affecting different systems, such as cardiovascular, pulmonary, gastrointestinal, and neurological. This narrative review explores the relationship between environmental stressors and neuropathological mechanisms, such as microglial and astrocytic activation, oxidative stress, and neuronal injury, involved in neuroinflammation and the associated neurodegeneration. The pathogenesis and progression of Alzheimer’s disease is discussed in detail, establishing a link between environmental stressors and neuroinflammation. A deeper understanding of these neuropathological mechanisms may guide the development of preventive and therapeutic strategies to safeguard brain health in the context of global environmental change.
Keywords: neuroinflammation; environment; climate change; pollution; Alzheimer’s disease neuroinflammation; environment; climate change; pollution; Alzheimer’s disease

Share and Cite

MDPI and ACS Style

Caldarelli, M.; Rio, P.; Gasbarrini, A.; Gambassi, G.; Cianci, R. Environmental Stressors and Neuroinflammation: Linking Climate Change to Alzheimer’s Disease. Curr. Issues Mol. Biol. 2025, 47, 959. https://doi.org/10.3390/cimb47110959

AMA Style

Caldarelli M, Rio P, Gasbarrini A, Gambassi G, Cianci R. Environmental Stressors and Neuroinflammation: Linking Climate Change to Alzheimer’s Disease. Current Issues in Molecular Biology. 2025; 47(11):959. https://doi.org/10.3390/cimb47110959

Chicago/Turabian Style

Caldarelli, Mario, Pierluigi Rio, Antonio Gasbarrini, Giovanni Gambassi, and Rossella Cianci. 2025. "Environmental Stressors and Neuroinflammation: Linking Climate Change to Alzheimer’s Disease" Current Issues in Molecular Biology 47, no. 11: 959. https://doi.org/10.3390/cimb47110959

APA Style

Caldarelli, M., Rio, P., Gasbarrini, A., Gambassi, G., & Cianci, R. (2025). Environmental Stressors and Neuroinflammation: Linking Climate Change to Alzheimer’s Disease. Current Issues in Molecular Biology, 47(11), 959. https://doi.org/10.3390/cimb47110959

Article Metrics

Back to TopTop