Ferroptosis-Related lncRNA to Predict the Clinical Outcomes and Molecular Characteristics of Kidney Renal Papillary Cell Carcinoma
Abstract
:1. Introduction
2. Results
2.1. Identify FRLs Using Bioinformatic Approaches
2.2. Construction of FRMto Predict the OS of Patients with KIRP
2.3. Differentially Expressed Genes Revealed Cell Metabolic Alterations Associated with FRM Risk in KIRP
2.4. Differences in the Immune Microenvironment and Immune-Related Signatures between the High and Low-Risk Groups of FRM
2.5. Comparison of the Differential Expression of Ferroptosis Regulators in KIRPs with Different FRM Risk Scores
2.6. Identification of the FRM Risk-Associated Mutation Landscape in KIRP Samples
2.7. Comparison of the Sensitivity to Anticancer Drugs between Patients with Different FRM Risk Scores
2.8. Singer-Cell Analysis
3. Discussion
4. Materials and Methods
4.1. Collection of Data
4.2. Identification of FRLs and DEFRGs
4.3. Establishment of a Risk Model for Evaluating the Risk Score
4.4. Functional Enrichment Analysis
4.5. Construction of the ceRNA Network
4.6. Estimation of Intratumoral Immune Cell Infiltration
4.7. The Significance of FRM in Drug Sensitivity
4.8. Singer-Cell Analysis
4.9. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gong, Y.; Zhang, C.; Li, H.; Yu, X.; Li, Y.; Liu, Z.; He, R. Ferroptosis-Related lncRNA to Predict the Clinical Outcomes and Molecular Characteristics of Kidney Renal Papillary Cell Carcinoma. Curr. Issues Mol. Biol. 2024, 46, 1886-1903. https://doi.org/10.3390/cimb46030123
Gong Y, Zhang C, Li H, Yu X, Li Y, Liu Z, He R. Ferroptosis-Related lncRNA to Predict the Clinical Outcomes and Molecular Characteristics of Kidney Renal Papillary Cell Carcinoma. Current Issues in Molecular Biology. 2024; 46(3):1886-1903. https://doi.org/10.3390/cimb46030123
Chicago/Turabian StyleGong, Yubo, Chenchen Zhang, Hao Li, Xiaojie Yu, Yuejia Li, Zhiguo Liu, and Ruyi He. 2024. "Ferroptosis-Related lncRNA to Predict the Clinical Outcomes and Molecular Characteristics of Kidney Renal Papillary Cell Carcinoma" Current Issues in Molecular Biology 46, no. 3: 1886-1903. https://doi.org/10.3390/cimb46030123