Long-Term Administration of LL-37 Can Induce Irreversible Rosacea-like Lesion
Abstract
1. Introduction
2. Materials and Methods
2.1. Animal Experiments
2.2. Histological Examination of Skin Tissue
2.3. Immunofluorescence Staining
2.4. Western Blot
2.5. Statistical Analysis
3. Results
3.1. The Degree of Rosacea-like Skin Lesions Induced by Long-Term LL-37 Administration Was More Severe Than Those Induced by Short-Term Administration
3.2. Rosacea-like Lesions Induced by Short-Term LL-37 Administration Were Able to Recover Spontaneously
3.3. Rosacea-like Lesions Induced by Long-Term LL-37 Administration Did Not Fully Recover on Their Own
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Zhang, C.; Kang, Y.; Zhang, Z.; Liu, H.; Xu, H.; Cai, W.; Gao, X.; Yang, J. Long-Term Administration of LL-37 Can Induce Irreversible Rosacea-like Lesion. Curr. Issues Mol. Biol. 2023, 45, 2703-2716. https://doi.org/10.3390/cimb45040177
Zhang C, Kang Y, Zhang Z, Liu H, Xu H, Cai W, Gao X, Yang J. Long-Term Administration of LL-37 Can Induce Irreversible Rosacea-like Lesion. Current Issues in Molecular Biology. 2023; 45(4):2703-2716. https://doi.org/10.3390/cimb45040177
Chicago/Turabian StyleZhang, Chuanxi, Yumeng Kang, Ziyan Zhang, Heliang Liu, Hong Xu, Wenchen Cai, Xuemin Gao, and Jie Yang. 2023. "Long-Term Administration of LL-37 Can Induce Irreversible Rosacea-like Lesion" Current Issues in Molecular Biology 45, no. 4: 2703-2716. https://doi.org/10.3390/cimb45040177
APA StyleZhang, C., Kang, Y., Zhang, Z., Liu, H., Xu, H., Cai, W., Gao, X., & Yang, J. (2023). Long-Term Administration of LL-37 Can Induce Irreversible Rosacea-like Lesion. Current Issues in Molecular Biology, 45(4), 2703-2716. https://doi.org/10.3390/cimb45040177