The Role of Ubiquitination in Regulation of Innate Immune Signaling

Ali Zohaib; Xiaodong Duan; Bibo Zhu; Jing Ye; Shengfeng Wan; Huanchun Chen; Xueqin Liu; Shengbo Cao

doi:10.21775/cimb.018.001

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30 March 2015

The Role of Ubiquitination in Regulation of Innate Immune Signaling

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State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, Hubei, China

Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, China

Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China

Authors to whom correspondence should be addressed.

Curr. Issues Mol. Biol.2016, 18(1), 1-10;https://doi.org/10.21775/cimb.018.001

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Abstract

Ubiquitination, also denoted ubiquitylation, is a posttranslational modification that has been implicated in the regulation of both innate and adaptive immune responses. Ubiquitination plays crucial roles in innate immune signaling by ensuring the proper orchestration of several signaling mediators that constitute a functional immune response. Herein, we briefly summarize the latest discoveries concerning the molecular ubiquitination-related machinery that senses, assembles, and disassembles innate immune signaling mediators.

Keywords:

ubiquitination; ubiquitylation; posttranslational modification immune responses; immune signaling; signaling mediators

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