Next Article in Journal
Pharmacologic Evaluation of Antidepressant Activity and Synthesis of 2-Morpholino-5-phenyl-6H-1,3,4-thiadiazine Hydrobromide
Next Article in Special Issue
Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance
Previous Article in Journal
Chemical Variations on the p53 Reactivation Theme
Previous Article in Special Issue
3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach
Open AccessReview

How Efficient Is My (Medicinal) Chemistry?

Laboratory of Organic Chemistry, University of Mons-UMONS, Place du Parc 23, Mons B-7000, Belgium
Academic Editor: Derek J. McPhee
Pharmaceuticals 2016, 9(2), 26; https://doi.org/10.3390/ph9020026
Received: 27 January 2016 / Revised: 3 May 2016 / Accepted: 10 May 2016 / Published: 16 May 2016
(This article belongs to the Special Issue Choices of the Journal)
“Greening” a chemical transformation is not about only changing the nature of a solvent or decreasing the reaction temperature. There are metrics enabling a critical quantification of the efficiency of an experimental protocol. Some of them are applied to different sequences for the preparation of paracetamol in order to understand their performance parameters and elucidate pathways for improvement. View Full-Text
Keywords: atom economy; ecoscale; E factor; green chemistry; life cycle analysis; paracetamol; reaction mass efficiency; stoichiometric factor; waste; yield atom economy; ecoscale; E factor; green chemistry; life cycle analysis; paracetamol; reaction mass efficiency; stoichiometric factor; waste; yield
Show Figures

Graphical abstract

MDPI and ACS Style

Vanden Eynde, J.J. How Efficient Is My (Medicinal) Chemistry? Pharmaceuticals 2016, 9, 26.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop