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On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities

by Yufeng Wei 1,2
Department of Chemistry, New Jersery City University, 2039 Kennedy Blvd, Jersey City, NJ 07305, USA
Institute of NeuroImmune Pharmacology, Seton Hall University, 400 South Orange Ave, South Orange, NJ 07094, USA 
Academic Editor: Jean Jacques Vanden Eynde
Pharmaceuticals 2015, 8(3), 455-473;
Received: 1 April 2015 / Revised: 18 July 2015 / Accepted: 24 July 2015 / Published: 31 July 2015
Phosphoprotein enriched in astrocytes, 15 KDa (PEA-15), a ubiquitously expressed small protein in all mammals, is known for decades for its potent interactions with various protein partners along distinct biological pathways. Most notable interacting partners of PEA-15 include extracellular signal-regulated kinase 1 and 2 (ERK1/2) in the mitogen activated protein kinase (MAPK) pathway, the Fas-associated death domain (FADD) protein involving in the formation of the death-inducing signaling complex (DISC), and the phospholipase D1 (PLD1) affecting the insulin sensitivity. However, the actual cellular functions of PEA-15 are still mysterious, and the question why this protein is expressed in almost all cell and tissue types remains unanswered. Here we synthesize the most recent structural, biological, and clinical studies on PEA-15 with emphases on its anti-apoptotic, anti-proliferative, and anti-inflammative properties, and propose a converged protective role of PEA-15 that maintains the balance of death and survival in different cell types. Under conditions that this delicate balance is unsustainable, PEA-15 may become pathological and lead to various diseases, including cancers and diabetes. Targeting PEA-15 interactions, or the use of PEA-15 protein as therapeutics, may provide a wider window of opportunities to treat these diseases. View Full-Text
Keywords: PEA-15; MAP kinase; apoptosis; phosphorylation; protein-protein interaction PEA-15; MAP kinase; apoptosis; phosphorylation; protein-protein interaction
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Wei, Y. On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities. Pharmaceuticals 2015, 8, 455-473.

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