Next Article in Journal / Special Issue
Immunotherapeutic Applications of NK Cells
Previous Article in Journal
Design and Synthesis of Novel N-Arylsulfonyl-3-(2-yl-ethanone)-6-methylindole Derivatives as Inhibitors of HIV-1 Replication
Previous Article in Special Issue
Wharton’s Jelly-Derived Mesenchymal Stromal Cells as a Promising Cellular Therapeutic Strategy for the Management of Graft-versus-Host Disease
Open AccessReview

Seatbelts in CAR therapy: How Safe Are CARS?

1
Bone Marrow Transplantation and Cellular Therapy, University of Alabama at Birmingham, Birmingham, AL 35294-3300, USA
2
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030-2399, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Mark Murphy
Pharmaceuticals 2015, 8(2), 230-249; https://doi.org/10.3390/ph8020230
Received: 9 December 2014 / Revised: 29 April 2015 / Accepted: 4 May 2015 / Published: 8 May 2015
(This article belongs to the Special Issue Cell Therapy)
T-cells genetically redirected with a chimeric antigen receptor (CAR) to recognize tumor antigens and kill tumor cells have been infused in several phase 1 clinical trials with success. Due to safety concerns related to on-target/off-tumor effects or cytokine release syndrome, however, strategies to prevent or abate serious adverse events are required. Pharmacologic therapies; suicide genes; or novel strategies to limit the cytotoxic effect only to malignant cells are under active investigations. In this review, we summarize results and toxicities of investigations employing CAR redirected T-cells, with a focus on published strategies to grant safety of this promising cellular application. View Full-Text
Keywords: chimeric antigen receptor; suicide gene; safety switch; adoptive immunotherapy; cell therapy chimeric antigen receptor; suicide gene; safety switch; adoptive immunotherapy; cell therapy
Show Figures

Figure 1

MDPI and ACS Style

Minagawa, K.; Zhou, X.; Mineishi, S.; Di Stasi, A. Seatbelts in CAR therapy: How Safe Are CARS? Pharmaceuticals 2015, 8, 230-249.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop