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Seatbelts in CAR therapy: How Safe Are CARS?

Bone Marrow Transplantation and Cellular Therapy, University of Alabama at Birmingham, Birmingham, AL 35294-3300, USA
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030-2399, USA
Author to whom correspondence should be addressed.
Academic Editor: Mark Murphy
Pharmaceuticals 2015, 8(2), 230-249;
Received: 9 December 2014 / Revised: 29 April 2015 / Accepted: 4 May 2015 / Published: 8 May 2015
(This article belongs to the Special Issue Cell Therapy)
PDF [977 KB, uploaded 11 May 2015]


T-cells genetically redirected with a chimeric antigen receptor (CAR) to recognize tumor antigens and kill tumor cells have been infused in several phase 1 clinical trials with success. Due to safety concerns related to on-target/off-tumor effects or cytokine release syndrome, however, strategies to prevent or abate serious adverse events are required. Pharmacologic therapies; suicide genes; or novel strategies to limit the cytotoxic effect only to malignant cells are under active investigations. In this review, we summarize results and toxicities of investigations employing CAR redirected T-cells, with a focus on published strategies to grant safety of this promising cellular application. View Full-Text
Keywords: chimeric antigen receptor; suicide gene; safety switch; adoptive immunotherapy; cell therapy chimeric antigen receptor; suicide gene; safety switch; adoptive immunotherapy; cell therapy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Minagawa, K.; Zhou, X.; Mineishi, S.; Di Stasi, A. Seatbelts in CAR therapy: How Safe Are CARS? Pharmaceuticals 2015, 8, 230-249.

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