Seatbelts in CAR therapy: How Safe Are CARS?
AbstractT-cells genetically redirected with a chimeric antigen receptor (CAR) to recognize tumor antigens and kill tumor cells have been infused in several phase 1 clinical trials with success. Due to safety concerns related to on-target/off-tumor effects or cytokine release syndrome, however, strategies to prevent or abate serious adverse events are required. Pharmacologic therapies; suicide genes; or novel strategies to limit the cytotoxic effect only to malignant cells are under active investigations. In this review, we summarize results and toxicities of investigations employing CAR redirected T-cells, with a focus on published strategies to grant safety of this promising cellular application. View Full-Text
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Minagawa, K.; Zhou, X.; Mineishi, S.; Di Stasi, A. Seatbelts in CAR therapy: How Safe Are CARS? Pharmaceuticals 2015, 8, 230-249.
Minagawa K, Zhou X, Mineishi S, Di Stasi A. Seatbelts in CAR therapy: How Safe Are CARS? Pharmaceuticals. 2015; 8(2):230-249.Chicago/Turabian Style
Minagawa, Kentaro; Zhou, Xiaoou; Mineishi, Shin; Di Stasi, Antonio. 2015. "Seatbelts in CAR therapy: How Safe Are CARS?" Pharmaceuticals 8, no. 2: 230-249.