Next Article in Journal
Does Amifostine Reduce Metabolic Rate? Effect of the Drug on Gas Exchange and Acute Ventilatory Hypoxic Response in Humans
Previous Article in Journal
Reactive Oxygen Species, Apoptosis, Antimicrobial Peptides and Human Inflammatory Diseases
Open AccessCommunication

Edaravone Enhances Brain-Derived Neurotrophic Factor Production in the Ischemic Mouse Brain

Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Pharmaceuticals 2015, 8(2), 176-185; https://doi.org/10.3390/ph8020176
Received: 24 February 2015 / Revised: 24 March 2015 / Accepted: 26 March 2015 / Published: 2 April 2015
Edaravone, a clinical drug used to treat strokes, protects against neuronal cell death and memory loss in the ischemic brains of animal models through its antioxidant activity. In the present study, we subcutaneously administrated edaravone to mice (3 mg/kg/day) for three days immediately after bilateral common carotid artery occlusion, and revealed through an immunohistochemical analysis that edaravone (1) accelerated increases in the production of brain-derived neurotrophic factor (BDNF) in the hippocampus; (2) increased the number of doublecortin-positive neuronal precursor cells in the dentate gyrus subgranular zone; and (3) suppressed the ischemia-induced inactivation of calcium-calmodulin-dependent protein kinase II in the hippocampus. We also revealed through a Western blotting analysis that edaravone (4) induced the phosphorylation of cAMP response element-binding (CREB), a transcription factor that regulates BDNF gene expression; and (5) induced the phosphorylation of extracellular signal-regulated kinases 1/2, an upstream signal factor of CREB. These results suggest that the neuroprotective effects of edaravone following brain ischemia were mediated not only by the elimination of oxidative stress, but also by the induction of BDNF production. View Full-Text
Keywords: edaravone; global cerebral ischemia; hippocampus; BDNF; neurogenesis; CaMK II edaravone; global cerebral ischemia; hippocampus; BDNF; neurogenesis; CaMK II
Show Figures

Figure 1

MDPI and ACS Style

Okuyama, S.; Morita, M.; Sawamoto, A.; Terugo, T.; Nakajima, M.; Furukawa, Y. Edaravone Enhances Brain-Derived Neurotrophic Factor Production in the Ischemic Mouse Brain. Pharmaceuticals 2015, 8, 176-185.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop