Next Article in Journal
Relationships between Cargo, Cell Penetrating Peptides and Cell Type for Uptake of Non-Covalent Complexes into Live Cells
Previous Article in Journal
siRNA Genome Screening Approaches to Therapeutic Drug Repositioning
Open AccessReview

Dendrimers for siRNA Delivery

Center for Pharmaceutical Biotechnology and Nanomedicine, 360 Huntington Ave, 140 The Fenway, Northeastern University, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2013, 6(2), 161-183; https://doi.org/10.3390/ph6020161
Received: 7 January 2013 / Revised: 17 January 2013 / Accepted: 29 January 2013 / Published: 4 February 2013
Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups. In recent years, dendrimers have been studied extensively for their potential application as carriers for nucleic acid therapeutics, which utilize the cationic charge of the dendrimers for effective dendrimer-nucleic acid condensation. siRNA is considered a promising, versatile tool among various RNAi-based therapeutics, which can effectively regulate gene expression if delivered successfully inside the cells. This review reports on the advancements in the development of dendrimers as siRNA carriers. View Full-Text
Keywords: dendrimer; siRNA; delivery dendrimer; siRNA; delivery
Show Figures

Figure 1

MDPI and ACS Style

Biswas, S.; Torchilin, V.P. Dendrimers for siRNA Delivery. Pharmaceuticals 2013, 6, 161-183. https://doi.org/10.3390/ph6020161

AMA Style

Biswas S, Torchilin VP. Dendrimers for siRNA Delivery. Pharmaceuticals. 2013; 6(2):161-183. https://doi.org/10.3390/ph6020161

Chicago/Turabian Style

Biswas, Swati; Torchilin, Vladimir P. 2013. "Dendrimers for siRNA Delivery" Pharmaceuticals 6, no. 2: 161-183. https://doi.org/10.3390/ph6020161

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop