Next Article in Journal
Relationships between Cargo, Cell Penetrating Peptides and Cell Type for Uptake of Non-Covalent Complexes into Live Cells
Previous Article in Journal
siRNA Genome Screening Approaches to Therapeutic Drug Repositioning
Article Menu

Export Article

Open AccessReview
Pharmaceuticals 2013, 6(2), 161-183;

Dendrimers for siRNA Delivery

Center for Pharmaceutical Biotechnology and Nanomedicine, 360 Huntington Ave, 140 The Fenway, Northeastern University, Boston, MA 02115, USA
Author to whom correspondence should be addressed.
Received: 7 January 2013 / Revised: 17 January 2013 / Accepted: 29 January 2013 / Published: 4 February 2013
Full-Text   |   PDF [581 KB, uploaded 4 February 2013]   |  


Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups. In recent years, dendrimers have been studied extensively for their potential application as carriers for nucleic acid therapeutics, which utilize the cationic charge of the dendrimers for effective dendrimer-nucleic acid condensation. siRNA is considered a promising, versatile tool among various RNAi-based therapeutics, which can effectively regulate gene expression if delivered successfully inside the cells. This review reports on the advancements in the development of dendrimers as siRNA carriers. View Full-Text
Keywords: dendrimer; siRNA; delivery dendrimer; siRNA; delivery

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Biswas, S.; Torchilin, V.P. Dendrimers for siRNA Delivery. Pharmaceuticals 2013, 6, 161-183.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top