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Correction published on 24 September 2012, see Pharmaceuticals 2012, 5(9), 1044.
Open AccessArticle

Synthesis and Spectroscopic Analysis of Novel 1H-Benzo[d]imidazoles Phenyl Sulfonylpiperazines

1
Pharmaceutical Sciences Department, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 11426, Saudi Arabia
2
Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan
Pharmaceuticals 2012, 5(5), 460-468; https://doi.org/10.3390/ph5050460
Received: 18 March 2012 / Revised: 18 April 2012 / Accepted: 27 April 2012 / Published: 3 May 2012
A group of benzimidazole analogs of sildenafil, 3-benzimidazolyl-4-methoxy-phenylsulfonylpiperazines 2–4 and 3-benzimidazolyl-4-methoxy-N,N-dimethyl- benzenesulfonamide (5), were efficiently synthesized. Compounds 2–5 were characterized by NMR and MS and contrary to the reported mass spectra of sildenafil, the spectra of the piperazine-containing compounds 2–4 showed a novel fragmentation pattern leading to an m/z = 316. A mechanism for the formation of this fragment was proposed. View Full-Text
Keywords: phenyl sulfonylpiperazine; benzimidazole; mass spectrometry; NMR phenyl sulfonylpiperazine; benzimidazole; mass spectrometry; NMR
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MDPI and ACS Style

Qandil, A.M. Synthesis and Spectroscopic Analysis of Novel 1H-Benzo[d]imidazoles Phenyl Sulfonylpiperazines. Pharmaceuticals 2012, 5, 460-468. https://doi.org/10.3390/ph5050460

AMA Style

Qandil AM. Synthesis and Spectroscopic Analysis of Novel 1H-Benzo[d]imidazoles Phenyl Sulfonylpiperazines. Pharmaceuticals. 2012; 5(5):460-468. https://doi.org/10.3390/ph5050460

Chicago/Turabian Style

Qandil, Amjad M. 2012. "Synthesis and Spectroscopic Analysis of Novel 1H-Benzo[d]imidazoles Phenyl Sulfonylpiperazines" Pharmaceuticals 5, no. 5: 460-468. https://doi.org/10.3390/ph5050460

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