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Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks

Department of Rheumatology and Clinical Immunology, Medisch Spectrum Twente and University of Twente, Ariensplein 1, 7500 KA Enschede, The Netherlands
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(7), 2146-2162;
Received: 17 June 2010 / Revised: 30 June 2010 / Accepted: 1 July 2010 / Published: 7 July 2010
(This article belongs to the Special Issue Non-Steroidal Anti-Inflammatory Drugs)
While aspirin may offer protection, other non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) can cause serious cardiovascular side effects and complications. This has led to a general "black box" warning for cardiovascular adverse events for NSAIDs. This review explores the different mechanisms underlying the protective effects of aspirin, the NSAID associated renovascular effects causing hypertension, edema and heart failure, the cardiovascular effects causing myocardial infarction and stroke, and the possible deleterious interaction between NSAIDs and aspirin. View Full-Text
Keywords: NSAIDs; aspirin; cardiovascular events NSAIDs; aspirin; cardiovascular events
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Meek, I.L.; Van de Laar, M.A.; E. Vonkeman, H. Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks. Pharmaceuticals 2010, 3, 2146-2162.

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