Next Article in Journal
Beneficial and Harmful Interactions of Antibiotics with Microbial Pathogens and the Host Innate Immune System
Next Article in Special Issue
The Role of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in the Management of the Post-Embolization Symptoms after Uterine Artery Embolization
Previous Article in Journal / Special Issue
NSAIDs: Old Drugs Reveal New Anticancer Targets

Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing

Department of Biochemistry & Molecular Biology, University of Medicine and Dentistry of New Jersey—New Jersey Medical School, Newark, NJ 07013, USA
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(5), 1668-1693;
Received: 9 April 2010 / Revised: 5 May 2010 / Accepted: 24 May 2010 / Published: 25 May 2010
(This article belongs to the Special Issue Non-Steroidal Anti-Inflammatory Drugs)
Nonspecific and COX-2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) function by inhibiting the cyclooxygenase isoenzymes and effectively reduce pain and inflammation attributed to acute or chronic musculoskeletal pathologies. However, use of NSAIDs as an analgesic is thought to negatively contribute to bone healing. This review strived to provide a thorough unbiased analysis of the current research conducted on animals and humans regarding NSAIDs and their effect on bone healing. Specifically, this review discusses the role of animal models, dosing regiments, and outcome parameters when examining discrepancies about NSAIDS and their effects on bone regeneration. The role of COX-2 in bone regeneration needs to be better defined in order to further elucidate the impact of NSAIDs on bone healing. View Full-Text
Keywords: NSAIDs; bone healing; COX-2; COX-1; fracture NSAIDs; bone healing; COX-2; COX-1; fracture
Show Figures

Figure 1

MDPI and ACS Style

Cottrell, J.; O’Connor, J.P. Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing. Pharmaceuticals 2010, 3, 1668-1693.

AMA Style

Cottrell J, O’Connor JP. Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing. Pharmaceuticals. 2010; 3(5):1668-1693.

Chicago/Turabian Style

Cottrell, Jessica, and J. Patrick O’Connor. 2010. "Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing" Pharmaceuticals 3, no. 5: 1668-1693.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop