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Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing

Department of Biochemistry & Molecular Biology, University of Medicine and Dentistry of New Jersey—New Jersey Medical School, Newark, NJ 07013, USA
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(5), 1668-1693;
Received: 9 April 2010 / Revised: 5 May 2010 / Accepted: 24 May 2010 / Published: 25 May 2010
(This article belongs to the Special Issue Non-Steroidal Anti-Inflammatory Drugs)
PDF [266 KB, uploaded 25 May 2010]


Nonspecific and COX-2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) function by inhibiting the cyclooxygenase isoenzymes and effectively reduce pain and inflammation attributed to acute or chronic musculoskeletal pathologies. However, use of NSAIDs as an analgesic is thought to negatively contribute to bone healing. This review strived to provide a thorough unbiased analysis of the current research conducted on animals and humans regarding NSAIDs and their effect on bone healing. Specifically, this review discusses the role of animal models, dosing regiments, and outcome parameters when examining discrepancies about NSAIDS and their effects on bone regeneration. The role of COX-2 in bone regeneration needs to be better defined in order to further elucidate the impact of NSAIDs on bone healing. View Full-Text
Keywords: NSAIDs; bone healing; COX-2; COX-1; fracture NSAIDs; bone healing; COX-2; COX-1; fracture

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Cottrell, J.; O’Connor, J.P. Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing. Pharmaceuticals 2010, 3, 1668-1693.

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