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Pharmaceuticals 2010, 3(5), 1456-1490;

Building Cell Selectivity into CPP-Mediated Strategies

Institute for Research in Biomedicine (IRB Barcelona), Barcelona Science Park, Baldiri Reixac 10, Barcelona, Spain
Department of Organic Chemistry, University of Barcelona, Martí i Franquès 1-11, Barcelona, Spain
Authors to whom correspondence should be addressed.
Received: 8 January 2010 / Revised: 29 April 2010 / Accepted: 5 May 2010 / Published: 14 May 2010
(This article belongs to the Special Issue Cell-penetrating Peptides 2012)
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There is a pressing need for more effective and selective therapies for cancer and other diseases. Consequently, much effort is being devoted to the development of alternative experimental approaches based on selective systems, which are designed to be specifically directed against target cells. In addition, a large number of highly potent therapeutic molecules are being discovered. However, they do not reach clinical trials because of their low delivery, poor specificity or their incapacity to bypass the plasma membrane. Cell-penetrating peptides (CPPs) are an open door for cell-impermeable compounds to reach intracellular targets. Putting all these together, research is sailing in the direction of the design of systems with the capacity to transport new drugs into a target cell. Some CPPs show cell type specificity while others require modifications or form part of more sophisticated drug delivery systems. In this review article we summarize several strategies for directed drug delivery involving CPPs that have been reported in the literature. View Full-Text
Keywords: cell-penetrating peptides (CPPs); targeted drug delivery; homing peptides; selective targeting; peptide transduction domains (PTDs) cell-penetrating peptides (CPPs); targeted drug delivery; homing peptides; selective targeting; peptide transduction domains (PTDs)

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Martín, I.; Teixidó, M.; Giralt, E. Building Cell Selectivity into CPP-Mediated Strategies. Pharmaceuticals 2010, 3, 1456-1490.

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