Next Article in Journal
Natural Products in Epilepsy—the Present Situation and Perspectives for the Future
Next Article in Special Issue
The Molecular Mechanisms of Anesthetic Action: Updates and Cutting Edge Developments from the Field of Molecular Modeling
Previous Article in Journal
Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts – Crucial ‘Human Osteoclastology’
Open AccessReview

Acid-Sensing Ion Channels and Pain

Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536-0298, USA
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(5), 1411-1425; https://doi.org/10.3390/ph3051411
Received: 2 April 2010 / Revised: 14 April 2010 / Accepted: 7 May 2010 / Published: 11 May 2010
(This article belongs to the Special Issue Ion Channels as Therapeutic Targets for Pain)
Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management. View Full-Text
Keywords: acid sensing ion channel; acidosis; inflammation; nociceptor; pain acid sensing ion channel; acidosis; inflammation; nociceptor; pain
Show Figures

Figure 1

MDPI and ACS Style

Gu, Q.; Lee, L.-Y. Acid-Sensing Ion Channels and Pain. Pharmaceuticals 2010, 3, 1411-1425.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop