Nitroaromatic Hypoxia-Activated Prodrugs for Cancer Therapy
Abstract
:1. Introduction: The Problem of Tumour Hypoxia
2. Prodrugs Activated by Electron Redistribution
3. Prodrugs Activated by Fragmentation
3.1. 4-Nitrobenzyl Triggers
3.2. Nitrophenyl Triggers
3.3. 2-Nitroimidazole Triggers
3.4. 4-Nitroimidazole Triggers
3.5. Other Nitroheterocyclic Triggers
3.6. Nitrobenzo[e]indole Prodrugs
4. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Cmpd | E1 (mV) | C10 Air (µM) | C10 N2 (µM) | HR |
---|---|---|---|---|
72 | −277 | 22 | 1.3 | 16 |
73 | −287 | 3450 | 2.2 | 2500 |
74 | −344 | 30 | 4.5 | 14 |
75 | −361 | 30 | 6 | 6 |
76 | −397 | 57 | 1.2 | 46 |
77 | −500 | 245 | 18 | 16 |
78 | 1.0 | 0.85 | 1.17 |
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Denny, W.A. Nitroaromatic Hypoxia-Activated Prodrugs for Cancer Therapy. Pharmaceuticals 2022, 15, 187. https://doi.org/10.3390/ph15020187
Denny WA. Nitroaromatic Hypoxia-Activated Prodrugs for Cancer Therapy. Pharmaceuticals. 2022; 15(2):187. https://doi.org/10.3390/ph15020187
Chicago/Turabian StyleDenny, William A. 2022. "Nitroaromatic Hypoxia-Activated Prodrugs for Cancer Therapy" Pharmaceuticals 15, no. 2: 187. https://doi.org/10.3390/ph15020187