Use of 3D Printing for the Development of Biodegradable Antiplatelet Materials for Cardiovascular Applications
Abstract
:1. Introduction
2. Results
2.1. Three-Dimensional Printing of PCL-Based Materials Loaded with ASA
2.2. Characterisation of Tubular 3D-Printed Tubular Grafts
2.3. ASA Release Kinetics
2.4. Platelet Adhesion Study
2.5. Three-Dimensional Printing and Characterization of Grafts Containing RIF
2.6. Cell Proliferation Study
3. Discussion
4. Materials and Methods
4.1. Materials
4.2. Three-Dimensional Printed Tubular Grafts Design and Manufacture
4.3. Characterisation of the 3D-Printed Materials
4.4. ASA Release Kinetics
4.5. Platelet Adhesion Study
4.6. Cell Proliferation Study
4.7. Microbiological Assay
4.8. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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ASA (%) | Korsmeyer–Peppas | Higuchi | Zero-Order | ||||
---|---|---|---|---|---|---|---|
KKP | n | r2 | KH | r2 | KZO | r2 | |
5 | 0.34 ± 0.01 | 0.45 ± 0.01 | 0.9930 | 0.32 ± 0.01 | 0.9899 | 0.14 ± 0.03 | 0.8820 |
10 | 0.32 ± 0.01 | 0.54 ± 0.02 | 0.9920 | 0.33 ± 0.01 | 0.9974 | 0.18 ± 0.02 | 0.9483 |
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Domínguez-Robles, J.; Diaz-Gomez, L.; Utomo, E.; Shen, T.; Picco, C.J.; Alvarez-Lorenzo, C.; Concheiro, A.; Donnelly, R.F.; Larrañeta, E. Use of 3D Printing for the Development of Biodegradable Antiplatelet Materials for Cardiovascular Applications. Pharmaceuticals 2021, 14, 921. https://doi.org/10.3390/ph14090921
Domínguez-Robles J, Diaz-Gomez L, Utomo E, Shen T, Picco CJ, Alvarez-Lorenzo C, Concheiro A, Donnelly RF, Larrañeta E. Use of 3D Printing for the Development of Biodegradable Antiplatelet Materials for Cardiovascular Applications. Pharmaceuticals. 2021; 14(9):921. https://doi.org/10.3390/ph14090921
Chicago/Turabian StyleDomínguez-Robles, Juan, Luis Diaz-Gomez, Emilia Utomo, Tingjun Shen, Camila J. Picco, Carmen Alvarez-Lorenzo, Angel Concheiro, Ryan F. Donnelly, and Eneko Larrañeta. 2021. "Use of 3D Printing for the Development of Biodegradable Antiplatelet Materials for Cardiovascular Applications" Pharmaceuticals 14, no. 9: 921. https://doi.org/10.3390/ph14090921