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Review

Metal-Based G-Quadruplex Binders for Cancer Theranostics

1
C2TN-Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela LRS, Portugal
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CICS-UBI-Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal
3
DECN-Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela LRS, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Alexandra Paulo
Pharmaceuticals 2021, 14(7), 605; https://doi.org/10.3390/ph14070605
Received: 27 May 2021 / Revised: 21 June 2021 / Accepted: 21 June 2021 / Published: 23 June 2021
(This article belongs to the Special Issue Quadruplex Nucleic Acid Ligands in Drug Discovery)
The ability of fluorescent small molecules, such as metal complexes, to selectively recognize G-quadruplex (G4) structures has opened a route to develop new probes for the visualization of these DNA structures in cells. The main goal of this review is to update the most recent research efforts towards the development of novel cancer theranostic agents using this type of metal-based probes that specifically recognize G4 structures. This encompassed a comprehensive overview of the most significant progress in the field, namely based on complexes with Cu, Pt, and Ru that are among the most studied metals to obtain this class of molecules. It is also discussed the potential interest of obtaining G4-binders with medical radiometals (e.g., 99mTc, 111In, 64Cu, 195mPt) suitable for diagnostic and/or therapeutic applications within nuclear medicine modalities, in order to enable their theranostic potential. View Full-Text
Keywords: G-quadruplexes; telomerase; oncogene promoters; cancer theranostics; metal complexes; fluorescent probes; radioprobes G-quadruplexes; telomerase; oncogene promoters; cancer theranostics; metal complexes; fluorescent probes; radioprobes
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MDPI and ACS Style

Palma, E.; Carvalho, J.; Cruz, C.; Paulo, A. Metal-Based G-Quadruplex Binders for Cancer Theranostics. Pharmaceuticals 2021, 14, 605. https://doi.org/10.3390/ph14070605

AMA Style

Palma E, Carvalho J, Cruz C, Paulo A. Metal-Based G-Quadruplex Binders for Cancer Theranostics. Pharmaceuticals. 2021; 14(7):605. https://doi.org/10.3390/ph14070605

Chicago/Turabian Style

Palma, Elisa, Josué Carvalho, Carla Cruz, and António Paulo. 2021. "Metal-Based G-Quadruplex Binders for Cancer Theranostics" Pharmaceuticals 14, no. 7: 605. https://doi.org/10.3390/ph14070605

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