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Open AccessReview

Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761®)

1
Scientific Direction, IRCCS San Raffaele Roma, 00166 Rome, Italy
2
Department of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), University “Magna Graecia” of Catanzaro, 88201 Catanzaro, Italy
3
Clinica Medica “Frugoni” and Geriatric Medicine-Memory Unit, University of Bari Aldo Moro, 70122 Bari, Italy
4
Institute for Research on Pain, ISAL Foundation, Torre Pedrera, 47922 Rimini, Italy
5
Scientific Department, Schwabe Pharma Italia S.r.l., 39044 Egna, Italy
6
Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, 00166 Rome, Italy
7
Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Via di Val Cannuta, 247, 00166 Rome, Italy
8
Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy
9
Department of Neuroscience & Neurorehabilitation, IRCCS San Raffaele Roma, 00163 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Giulia Sita and Antoni Camins Espuny
Pharmaceuticals 2021, 14(4), 305; https://doi.org/10.3390/ph14040305
Received: 5 February 2021 / Revised: 15 March 2021 / Accepted: 26 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Treatment of Alzheimer Disease)
Mild cognitive impairment (MCI) and dementia are clinically prevalent in the elderly. There is a high risk of cognitive decline in patients diagnosed with MCI or dementia. This review describes the effectiveness of Ginkgo biloba leaf special extract EGb 761® for the treatment of dementia syndromes and EGb 761® combination therapy with other medications for symptomatic dementia. This drug has shown convincing results, improving cognitive function, neuropsychiatric symptoms and consequent reduction of caregiver stress and maintenance of autonomy in patients with age-related cognitive decline, MCI and mild to moderate dementia. Currently, there is little evidence to support the combination therapy with anti-dementia drugs and, therefore, more evidence is needed to evaluate the role of EGb 761® in mixed therapy. View Full-Text
Keywords: mild cognitive impairment (MCI); mild dementia; Alzheimer’s disease; Ginkgo biloba (Egb761®); Tebonin; anti-dementia drugs; randomized controlled trials mild cognitive impairment (MCI); mild dementia; Alzheimer’s disease; Ginkgo biloba (Egb761®); Tebonin; anti-dementia drugs; randomized controlled trials
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MDPI and ACS Style

Tomino, C.; Ilari, S.; Solfrizzi, V.; Malafoglia, V.; Zilio, G.; Russo, P.; Proietti, S.; Marcolongo, F.; Scapagnini, G.; Muscoli, C.; Rossini, P.M. Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761®). Pharmaceuticals 2021, 14, 305. https://doi.org/10.3390/ph14040305

AMA Style

Tomino C, Ilari S, Solfrizzi V, Malafoglia V, Zilio G, Russo P, Proietti S, Marcolongo F, Scapagnini G, Muscoli C, Rossini PM. Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761®). Pharmaceuticals. 2021; 14(4):305. https://doi.org/10.3390/ph14040305

Chicago/Turabian Style

Tomino, Carlo; Ilari, Sara; Solfrizzi, Vincenzo; Malafoglia, Valentina; Zilio, Guglielmo; Russo, Patrizia; Proietti, Stefania; Marcolongo, Federica; Scapagnini, Giovanni; Muscoli, Carolina; Rossini, Paolo M. 2021. "Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761®)" Pharmaceuticals 14, no. 4: 305. https://doi.org/10.3390/ph14040305

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