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Review

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

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Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, E-32004 Ourense, Spain
2
Centro de Investigação de Montanha (CIMO), Campus de Santa Apolonia, Instituto Politécnico de Bragança, 5300-253 Bragança, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editor: Paulo Santos
Pharmaceuticals 2021, 14(2), 157; https://doi.org/10.3390/ph14020157
Received: 31 December 2020 / Revised: 3 February 2021 / Accepted: 6 February 2021 / Published: 14 February 2021
(This article belongs to the Special Issue Anticancer Compounds in Medicinal Plants)
Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve mono-chemotherapy or a combination of radiotherapy and mono-chemotherapy. However, the negative side effects of these approaches have been extensively reported and have prompted the search of new therapeutic drugs. In this context, scientific community started to look for innovative sources of anticancer compounds in natural sources, including traditional plants. Currently, numerous studies have evaluated the anticancer properties of natural compounds derived from plants, both in vitro and in vivo. In pre-clinical stages, some promising compounds could be mentioned, such as the sulforaphane or different phenolic compounds. On the other hand, some phytochemicals obtained positive results in clinical stages and were further approved for cancer treatment, such as vinca alkaloids or the paclitaxel. Nevertheless, these compounds are not exempt of limitations, such as low solubility, restricted effect on their own, negative side-effects, etc. This review aims to compile the information about the current phytochemicals used for cancer treatment and also promising candidates, main action mechanisms and also reported limitations. In this sense, some strategies to face the limitations have been considered, such as nano-based formulations to improve solubility or chemical modification to reduce toxicity. In conclusion, although more research is still necessary to develop more efficient and safe phytochemical drugs, more of these compounds might be used in future cancer therapies. View Full-Text
Keywords: natural compounds; traditional plants; anticancer; clinical/pre-clinical studies; challenges natural compounds; traditional plants; anticancer; clinical/pre-clinical studies; challenges
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MDPI and ACS Style

Garcia-Oliveira, P.; Otero, P.; Pereira, A.G.; Chamorro, F.; Carpena, M.; Echave, J.; Fraga-Corral, M.; Simal-Gandara, J.; Prieto, M.A. Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment. Pharmaceuticals 2021, 14, 157. https://doi.org/10.3390/ph14020157

AMA Style

Garcia-Oliveira P, Otero P, Pereira AG, Chamorro F, Carpena M, Echave J, Fraga-Corral M, Simal-Gandara J, Prieto MA. Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment. Pharmaceuticals. 2021; 14(2):157. https://doi.org/10.3390/ph14020157

Chicago/Turabian Style

Garcia-Oliveira, Paula, Paz Otero, Antia G. Pereira, Franklin Chamorro, Maria Carpena, Javier Echave, Maria Fraga-Corral, Jesus Simal-Gandara, and Miguel A. Prieto. 2021. "Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment" Pharmaceuticals 14, no. 2: 157. https://doi.org/10.3390/ph14020157

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