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Article

Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats

1
UMR CNRS 5287 Aquitaine Institute for Integrative and Cognitive Neuroscience, University of Bordeaux, 33076 Bordeaux, France
2
Department of Symptom Research, MD Anderson Cancer Center, The University of Texas, Houston, TX 770030, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Alfredo Berzal-Herranz
Pharmaceuticals 2021, 14(10), 1030; https://doi.org/10.3390/ph14101030
Received: 2 September 2021 / Revised: 1 October 2021 / Accepted: 7 October 2021 / Published: 11 October 2021
(This article belongs to the Special Issue Cerebral Production and Action of Pro-inflammatory Cytokines)
Sickness behavior, characterized by on overall reduction in behavioral activity, is commonly observed after bacterial infection. Sickness behavior can also be induced by the peripheral administration of Gram-negative bacterial lipopolysaccharide (LPS) or interleukin-1beta (IL-1β), a pro-inflammatory cytokine released by LPS-activated macrophages. In addition to the microglia, the brain contains perivascular macrophages, which express the IL-1 type 1 receptor (IL-1R1). In the present study, we assessed the role of brain perivascular macrophages in mediating IL-1β-induced sickness behavior in rats. To do so, we used intracerebroventricular (icv) administration of an IL-1β-saporin conjugate, known to eliminate IL-R1-expressing brain cells, prior to systemic or central IL-1β injection. Icv IL-1β-saporin administration resulted in a reduction in brain perivascular macrophages, without altering subsequent icv or ip IL-1β-induced reductions in food intake, locomotor activity, and social interactions. In conclusion, the present work shows that icv IL-1β-saporin administration is an efficient way to target brain perivascular macrophages, and to determine whether these cells are involved in IL-1β-induced sickness behavior. View Full-Text
Keywords: brain perivascular macrophages; food intake; interleukin-1; locomotor activity; social interaction brain perivascular macrophages; food intake; interleukin-1; locomotor activity; social interaction
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MDPI and ACS Style

Chaskiel, L.; Dantzer, R.; Konsman, J.P. Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats. Pharmaceuticals 2021, 14, 1030. https://doi.org/10.3390/ph14101030

AMA Style

Chaskiel L, Dantzer R, Konsman JP. Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats. Pharmaceuticals. 2021; 14(10):1030. https://doi.org/10.3390/ph14101030

Chicago/Turabian Style

Chaskiel, Léa, Robert Dantzer, and Jan P. Konsman 2021. "Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats" Pharmaceuticals 14, no. 10: 1030. https://doi.org/10.3390/ph14101030

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