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Open AccessArticle

Antibacterial and Antifungal Activity of Propyl-Propane-Thiosulfinate and Propyl-Propane-Thiosulfonate, Two Organosulfur Compounds from Allium cepa: In Vitro Antimicrobial Effect via the Gas Phase

1
Department of Microbiology, School of Medicine and PhD Program in Clinical Medicine and Public Health, University of Granada-ibs, Avda. de la Investigación, 11, 18016 Granada, Spain
2
DMC Research Center, Camino de Jayena, 82, 18620 Alhendín, Spain
3
Laboratory of Microbiology, Virgen de las Nieves University Hospital-ibs, Avda. de las Fuerzas Armadas, 2, 18012 Granada, Spain
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2021, 14(1), 21; https://doi.org/10.3390/ph14010021
Received: 12 November 2020 / Revised: 9 December 2020 / Accepted: 23 December 2020 / Published: 29 December 2020
Propyl-propane thiosulfinate (PTS) and propyl-propane thiosulfonate (PTSO) are two volatile compounds derived from Allium cepa with a widely documented antimicrobial activity. The aim of this study was to evaluate their anti-candidiasis activity and the ability of its gaseous phase to inhibit bacterial and yeast growth in vitro. The minimum inhibitory concentration of various antifungal products (including PTS and PTSO) was determined versus 203 clinical isolates of Candida spp. through broth microdilution assay. Additionally, the antimicrobial activity through aerial diffusion of PTS and PTSO was evaluated over the growth of a collection of bacteria and yeasts cultivated in agar plates. All yeasts were susceptible to the antifungals tested, except C. glabrata and C. krusei, that showed azole resistance. PTSO (MIC50 and MIC90 ranged from 4 to 16 mg/L and 8 to 32 mg/L, respectively) was significantly more active against yeasts than PTS (MIC50 and MIC90 ranged from 16 to 64 mg/L and 32 to 64 mg/L). Values were higher than those obtained for antifungal drugs. Gaseous phases of PTS and PTSO generated growth inhibition zones whose diameters were directly related to the substances concentration and inversely related to the microbial inoculum. The quantification of PTS and PTSO levels reached in the growth media through aerial diffusion displayed a concentration gradient from the central zone to the periphery. Only P. aeruginosa ATCC 27853 showed resistance, while yeasts (C. albicans ATCC 200955 and C. krusei ATCC 6258) presented the higher susceptibility to both compounds. These results suggest that PTS and PTSO display antibacterial and anti-candidiasis activity in vitro through aerial diffusion, having potential use in human therapy. View Full-Text
Keywords: propyl-propane-thiosulfinate; propyl-propane-thiosulfonate; antibacterial activity; antifungal activity; vapor propyl-propane-thiosulfinate; propyl-propane-thiosulfonate; antibacterial activity; antifungal activity; vapor
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MDPI and ACS Style

Sorlozano-Puerto, A.; Albertuz-Crespo, M.; Lopez-Machado, I.; Gil-Martinez, L.; Ariza-Romero, J.J.; Maroto-Tello, A.; Baños-Arjona, A.; Gutierrez-Fernandez, J. Antibacterial and Antifungal Activity of Propyl-Propane-Thiosulfinate and Propyl-Propane-Thiosulfonate, Two Organosulfur Compounds from Allium cepa: In Vitro Antimicrobial Effect via the Gas Phase. Pharmaceuticals 2021, 14, 21. https://doi.org/10.3390/ph14010021

AMA Style

Sorlozano-Puerto A, Albertuz-Crespo M, Lopez-Machado I, Gil-Martinez L, Ariza-Romero JJ, Maroto-Tello A, Baños-Arjona A, Gutierrez-Fernandez J. Antibacterial and Antifungal Activity of Propyl-Propane-Thiosulfinate and Propyl-Propane-Thiosulfonate, Two Organosulfur Compounds from Allium cepa: In Vitro Antimicrobial Effect via the Gas Phase. Pharmaceuticals. 2021; 14(1):21. https://doi.org/10.3390/ph14010021

Chicago/Turabian Style

Sorlozano-Puerto, Antonio; Albertuz-Crespo, Maria; Lopez-Machado, Isaac; Gil-Martinez, Lidia; Ariza-Romero, Juan J.; Maroto-Tello, Alba; Baños-Arjona, Alberto; Gutierrez-Fernandez, Jose. 2021. "Antibacterial and Antifungal Activity of Propyl-Propane-Thiosulfinate and Propyl-Propane-Thiosulfonate, Two Organosulfur Compounds from Allium cepa: In Vitro Antimicrobial Effect via the Gas Phase" Pharmaceuticals 14, no. 1: 21. https://doi.org/10.3390/ph14010021

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