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Article

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

1
Department of Botany, Breeding and Agricultural Technology of Medicinal Plants, Institute of Natural Fibres and Medicinal Plants, Kolejowa 2, 62-064 Plewiska, Poland
2
Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants, Wojska Polskiego 71b, 60-630 Poznań, Poland
3
Chair and Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, Poland
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(7), 153; https://doi.org/10.3390/ph13070153
Received: 31 May 2020 / Revised: 10 July 2020 / Accepted: 14 July 2020 / Published: 16 July 2020
Curcumin, a principal bioactive substance of turmeric (Curcuma longa L.), is reported as a strong antioxidant, anti-inflammatory, antibacterial, antifungal, and antiviral agent. However, its antimicrobial properties require further detailed investigations into clinical and multidrug-resistant (MDR) isolates. In this work, we tested curcumin’s efficacy against over 100 strains of pathogens belonging to 19 species. This activity was determined by the broth microdilution method and by calculating the minimum inhibitory concentration (MIC). Our findings confirmed a much greater sensitivity of Gram-positive than Gram-negative bacteria. This study exhibited a significantly larger variation in the curcumin activity than previous works and suggested that numerous clinical strains of widespread pathogens have a poor sensitivity to curcumin. Similarly, the MICs of the MDR types of Staphylococcus aureus, S. haemolyticus, Escherichia coli, and Proteus mirabilis were high (≥2000 µg/mL). However, curcumin was effective against some species and strains: Streptococcus pyogenes (median MIC = 31.25 µg/mL), methicillin-sensitive S. aureus (250 µg/mL), Acinetobacter lwoffii (250 µg/mL), and individual strains of Enterococcus faecalis and Pseudomonas aeruginosa (62.5 µg/mL). The sensitivity of species was not associated with its affiliation to the genus, and it could differ a lot (e.g., S. pyogenes, S. agalactiae and A. lwoffii, A. baumannii). Hence, curcumin can be considered as a promising antibacterial agent, but with a very selective activity. View Full-Text
Keywords: Curcuma longa; curcumin; antibacterial activity; antifungal activity; minimum inhibitory concentration (MIC); multidrug-resistant (MDR) strains Curcuma longa; curcumin; antibacterial activity; antifungal activity; minimum inhibitory concentration (MIC); multidrug-resistant (MDR) strains
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MDPI and ACS Style

Adamczak, A.; Ożarowski, M.; Karpiński, T.M. Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity. Pharmaceuticals 2020, 13, 153. https://doi.org/10.3390/ph13070153

AMA Style

Adamczak A, Ożarowski M, Karpiński TM. Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity. Pharmaceuticals. 2020; 13(7):153. https://doi.org/10.3390/ph13070153

Chicago/Turabian Style

Adamczak, Artur; Ożarowski, Marcin; Karpiński, Tomasz M. 2020. "Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity" Pharmaceuticals 13, no. 7: 153. https://doi.org/10.3390/ph13070153

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