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Open AccessArticle

Study of In Vitro and In Vivo Carbamazepine Release from Coarse and Nanometric Pharmaceutical Emulsions Obtained via Ultra-High-Pressure Homogenization

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Programa de Maestría en Formulación de Productos Químicos y Derivados, Facultad de Ciencias Naturales, Universidad Icesi, Calle 18 No. 122-135, Cali 76003, Colombia
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Laboratorio de Diseño y Formulación de Productos Químicos y Derivados, Facultad de Ciencias Naturales. Universidad Icesi, Calle 18 No. 122-135, Cali 76003, Colombia
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Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Naturales, Universidad Icesi, Calle 18 No. 122-135, Cali 76003, Colombia
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Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(4), 53; https://doi.org/10.3390/ph13040053
Received: 17 February 2020 / Revised: 21 March 2020 / Accepted: 23 March 2020 / Published: 26 March 2020
(This article belongs to the Section Pharmaceutical Technology)
In the past decade, pharmaceutical nanotechnology has proven to be a promising alternative for improving the physicochemical and biopharmaceutical features for conventional pharmaceutical drug formulations. The goal of this study was to develop, characterize, and evaluate the in vitro and in vivo release of the model drug carbamazepine (CBZ) from two emulsified formulations with different droplet sizes (coarse and nanometric). Briefly, oil-in-water emulsions were developed using (i) Sacha inchi oil, ultrapure water, TweenTM 80, and SpanTM 80 as surfactants, (ii) methyl-paraben and propyl-paraben as preservatives, and (iii) CBZ as a nonpolar model drug. The coarse and nanometric emulsions were prepared by rotor–stator dispersion and ultra-high-pressure homogenization (UHPH), respectively. The in vitro drug release studies were conducted by dialysis, whereas the in vivo drug release was evaluated in New Zealand breed rabbits. The results showed that nanoemulsions were physically more stable than coarse emulsions, and that CBZ had a very low release for in vitro determination (<2%), and a release of 20% in the in vivo study. However, it was found that nanoemulsions could significantly increase drug absorption time from 12 h to 45 min. View Full-Text
Keywords: carbamazepine; coarse emulsion; in vitro/in vivo drug release; nanoemulsion; ultra-high-pressure homogenization carbamazepine; coarse emulsion; in vitro/in vivo drug release; nanoemulsion; ultra-high-pressure homogenization
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Echeverri, J.D.; Alhajj, M.J.; Montero, N.; Yarce, C.J.; Barrera-Ocampo, A.; Salamanca, C.H. Study of In Vitro and In Vivo Carbamazepine Release from Coarse and Nanometric Pharmaceutical Emulsions Obtained via Ultra-High-Pressure Homogenization. Pharmaceuticals 2020, 13, 53.

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