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Iron Therapeutics in Women’s Health: Past, Present, and Future

Department of Academic Affairs, Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, Davie, FL 33314, USA
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Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Pharmaceuticals 2020, 13(12), 449; https://doi.org/10.3390/ph13120449
Received: 4 October 2020 / Revised: 28 November 2020 / Accepted: 4 December 2020 / Published: 8 December 2020
(This article belongs to the Special Issue Iron as Therapeutic Targets in Human Diseases 2020)
Iron plays a unique physiological role in the maintenance of homeostasis and the pathological outcomes of the female reproductive tract. The dual nature of elemental iron has created an evolutionary need to tightly regulate its biological concentration. The female reproductive tract is particularly unique due to the constant cycle of endometrial growth and shedding, in addition to the potential need for iron transfer to a developing fetus. Here, iron regulation is explored in a number of physiologic states including the endometrial lining and placenta. While iron dysregulation is a common characteristic in many women’s health pathologies there is currently a lack of targeted therapeutic options. Traditional iron therapies, including iron replacement and chelation, are common treatment options for gynecological diseases but pose long term negative health consequences; therefore, more targeted interventions directed towards iron regulation have been proposed. Recent findings show potential benefits in a therapeutic focus on ferritin-hepcidin regulation, modulation of reactive oxygen species (ROS), and iron mediated cell death (ferroptosis). These novel therapeutics are the direct result of previous research in iron’s complex signaling pathway and show promise for improved therapy, diagnosis, and prognosis in women’s health. View Full-Text
Keywords: oxidative stress; carcinogenesis; mini-hepcidin; iron therapeutics oxidative stress; carcinogenesis; mini-hepcidin; iron therapeutics
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MDPI and ACS Style

Mintz, J.; Mirza, J.; Young, E.; Bauckman, K. Iron Therapeutics in Women’s Health: Past, Present, and Future. Pharmaceuticals 2020, 13, 449. https://doi.org/10.3390/ph13120449

AMA Style

Mintz J, Mirza J, Young E, Bauckman K. Iron Therapeutics in Women’s Health: Past, Present, and Future. Pharmaceuticals. 2020; 13(12):449. https://doi.org/10.3390/ph13120449

Chicago/Turabian Style

Mintz, Joel, Jackie Mirza, Eric Young, and Kyle Bauckman. 2020. "Iron Therapeutics in Women’s Health: Past, Present, and Future" Pharmaceuticals 13, no. 12: 449. https://doi.org/10.3390/ph13120449

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