Parkinson’s Disease Wearable Gait Analysis: Kinematic and Dynamic Markers for Diagnosis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Data Analysis
- Right and Left Stance, expressed both in seconds and as percentage of the stride length;
- Right and Left Swing, expressed both in seconds and as percentage of the stride length;
- Double Limb Supports, expressed both in seconds and as percentage of the stride length
- Right and Left Single Limb Supports, expressed both in seconds and as percentage of the stride length;
- Right and Left Step Duration, expressed both in seconds and as percentage of the stride length;
- Gait velocity expressed in m/s
- Time up and go test expressed in seconds
2.3. Dynamic Analysis
2.4. Kinematic Analysis
- Right and Left Stance, expressed both in seconds and as percentage of the stride length;
- Right and Left Swing, expressed both in seconds and as percentage of the stride length;
- Double Limb Supports, expressed both in seconds and as percentage of the stride length;
- Gait velocity expressed in m/s
- Time up and go test expressed in seconds
3. Results
3.1. Kinematic Analysis
- -
- Standard deviation (SD) left and right SWING absolute and percentage value
- -
- Standard deviation (SD) left and right STANCE percentage value
- -
- Standard deviation (SD) DOUBLE SUPPORT percentage value
- -
- Interquartile range (IQR) left and right SWING absolute and percentage value
- -
- Interquartile range (IQR) left and right STANCE absolute and percentage value
- -
- Interquartile range (IQR) DOUBLE SUPPORT percentage value
ROC Analysis
3.2. Dynamic Analysis
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Ref | Cohort | Dataset | Data Source | Group | Subjects Number | Gender | Age (m ± SD) | Hoehn and Yahr (m ± SD) | UPDRS (m ± SD) |
---|---|---|---|---|---|---|---|---|---|
[36] | 1 | 1 | Movement Disorders Unit at the Tel-Aviv Sourasky Medical Center | PD | 29 | 69% male | 71 ± 8 | 2.3 ± 0.4 | 33 ± 12 |
HS | 18 | 56% male | 72 ± 7 | ||||||
[37] | 2 | 1 | Movement Disorders Unit at the Tel Aviv Sourasky Medical Center | PD | 29 | 55% male | 67 ± 9 | 2.4 ± 0.4 | 25 ± 8 |
HS | 25 | 46% male | 65 ± 7 | ||||||
[30] | 3 | 1 | Movement Disorders Unit at the Tel-Aviv Sourasky Medical Center. | PD | 35 | 63% male | 62 ± 9 | 2.1 ± 0.2 | 36 ± 11 |
HS | 29 | 62% male | 58 ± 7 | ||||||
[38] | 4 | 2 | Neurology Outpatient Clinic at Massachusetts General Hospital. | PD | 15 | 67% male | 67 ± 11 | 2.8 ± 0.9 | |
HS | 16 | 13% male | 39 ± 19 |
First Dataset Cohort 1-2-3 | Second Dataset Cohort 4 |
---|---|
Type of Data Available | |
|
|
Data Manipulation | |
Kinematic Analysis:
| Kinematic Analysis:
|
Dynamic Analysis:
| Dynamic Analysis:
|
Variables | Group | N | Average | Standard Deviation | t | df | p Value | ||
---|---|---|---|---|---|---|---|---|---|
Kinematic | central tendency indices | Gait Speed (m/s) | HS | 88 | 1.260 | 0.166 | 8.278 | 194 | <0.001 * |
PD | 108 | 1.019 | 0.227 | ||||||
Time Up and Go (s) | HS | 62 | 9.300 | 1.604 | −5.187 | 150 | <0.001 * | ||
PD | 90 | 12.056 | 3.962 | ||||||
Ave left SWING | HS | 88 | 0.442 | 0.040 | 0.361 | 194 | 0.719 | ||
PD | 108 | 0.439 | 0.046 | ||||||
Ave right SWING | HS | 88 | 0.443 | 0.041 | 1.158 | 194 | 0.248 | ||
PD | 108 | 0.435 | 0.047 | ||||||
Ave left SWING % | HS | 88 | 41.804 | 3.143 | 1.951 | 194 | 0.053 | ||
PD | 108 | 40.781 | 4.018 | ||||||
Ave right SWING % | HS | 88 | 41.916 | 3.488 | 2.682 | 194 | 0.008 | ||
PD | 108 | 40.395 | 4.284 | ||||||
Ave left STANCE | HS | 88 | 0.618 | 0.071 | −2.127 | 194 | 0.035 | ||
PD | 108 | 0.646 | 0.109 | ||||||
Ave right STANCE | HS | 88 | 0.616 | 0.074 | −2.431 | 194 | 0.016 | ||
PD | 108 | 0.650 | 0.109 | ||||||
Ave left STANCE % | HS | 88 | 58.196 | 3.143 | −1.951 | 194 | 0.053 | ||
PD | 108 | 59.219 | 4.018 | ||||||
Ave right STANCE % | HS | 88 | 58.084 | 3.488 | −2.682 | 194 | 0.008 | ||
PD | 108 | 59.605 | 4.284 | ||||||
Ave DOUBLE SUPPORT | HS | 88 | 0.115 | 0.095 | −1.106 | 194 | 0.270 | ||
PD | 108 | 0.133 | 0.120 | ||||||
Ave DOUBLE SUPPORT % | HS | 88 | 10.681 | 8.528 | −0.808 | 194 | 0.420 | ||
PD | 108 | 11.734 | 9.492 | ||||||
Med left SWING | HS | 88 | 0.441 | 0.040 | 0.123 | 194 | 0.902 | ||
PD | 108 | 0.440 | 0.048 | ||||||
Med right SWING | HS | 88 | 0.442 | 0.041 | 0.963 | 194 | 0.337 | ||
PD | 108 | 0.436 | 0.047 | ||||||
Med left SWING % | HS | 88 | 41.999 | 3.195 | 1.844 | 194 | 0.067 | ||
PD | 108 | 41.029 | 4.003 | ||||||
Med right SWING % | HS | 88 | 42.064 | 3.487 | 2.502 | 194 | 0.013 | ||
PD | 108 | 40.655 | 4.240 | ||||||
Med left STANCE | HS | 88 | 0.611 | 0.069 | −2.043 | 194 | 0.042 | ||
PD | 108 | 0.638 | 0.106 | ||||||
Med right STANCE | HS | 88 | 0.611 | 0.073 | −2.303 | 194 | 0.022 | ||
PD | 108 | 0.642 | 0.106 | ||||||
Med left STANCE % | HS | 88 | 58.001 | 3.195 | −1.844 | 194 | 0.067 | ||
PD | 108 | 58.971 | 4.003 | ||||||
Med right STANCE % | HS | 88 | 57.936 | 3.487 | −2.502 | 194 | 0.013 | ||
PD | 108 | 59.345 | 4.240 | ||||||
Med DOUBLE SUPPORT | HS | 88 | 0.113 | 0.094 | −0.943 | 194 | 0.347 | ||
PD | 108 | 0.127 | 0.110 | ||||||
Med DOUBLE SUPPORT% | HS | 88 | 10.483 | 8.518 | −0.742 | 194 | 0.459 | ||
PD | 108 | 11.441 | 9.368 | ||||||
dispersion indices | SD left SWING | HS | 88 | 0.022 | 0.009 | −4.851 | 194 | <0.001 * | |
PD | 108 | 0.032 | 0.017 | ||||||
SD right SWING | HS | 88 | 0.022 | 0.008 | −4.357 | 194 | <0.001 * | ||
PD | 108 | 0.034 | 0.025 | ||||||
SD left SWING % | HS | 88 | 1.686 | 0.762 | −4.400 | 194 | <0.001 * | ||
PD | 108 | 2.357 | 1.254 | ||||||
SD right SWING % | HS | 88 | 1.568 | 0.613 | −6.093 | 194 | <0.001 * | ||
PD | 108 | 2.383 | 1.127 | ||||||
SD left STANCE | HS | 88 | 0.035 | 0.016 | −1.640 | 194 | 0.103 | ||
PD | 108 | 0.065 | 0.170 | ||||||
SD right STANCE | HS | 88 | 0.033 | 0.014 | −1.736 | 194 | 0.084 | ||
PD | 108 | 0.058 | 0.135 | ||||||
SD left STANCE % | HS | 88 | 1.686 | 0.762 | −4.400 | 194 | <0.001 * | ||
PD | 108 | 2.357 | 1.254 | ||||||
SD right STANCE % | HS | 88 | 1.568 | 0.613 | −6.093 | 194 | <0.001 * | ||
PD | 108 | 2.383 | 1.127 | ||||||
SD DOUBLE SUPPORT | HS | 88 | 0.019 | 0.015 | −1.441 | 194 | 0.151 | ||
PD | 108 | 0.045 | 0.171 | ||||||
SD DOUBLE SUPPORT % | HS | 88 | 1.386 | 0.718 | −3.396 | 194 | <0.001 * | ||
PD | 108 | 2.072 | 1.780 | ||||||
IQR left SWING | HS | 88 | 0.017 | 0.006 | −6.651 | 194 | <0.001 * | ||
PD | 108 | 0.027 | 0.014 | ||||||
IQR right SWING | HS | 88 | 0.017 | 0.006 | −5.821 | 194 | <0.001 * | ||
PD | 108 | 0.027 | 0.016 | ||||||
IQR left SWING % | HS | 88 | 1.326 | 0.323 | −6.279 | 194 | <0.001 * | ||
PD | 108 | 1.896 | 0.799 | ||||||
IQR right SWING % | HS | 88 | 1.229 | 0.337 | −7.009 | 194 | <0.001 * | ||
PD | 108 | 1.905 | 0.852 | ||||||
IQR left STANCE | HS | 88 | 0.026 | 0.009 | −4.577 | 194 | <0.001 * | ||
PD | 108 | 0.037 | 0.020 | ||||||
IQR right STANCE | HS | 88 | 0.026 | 0.009 | −4.902 | 194 | <0.001 * | ||
PD | 108 | 0.037 | 0.020 | ||||||
IQR left STANCE % | HS | 88 | 1.326 | 0.323 | −6.279 | 194 | <0.001 * | ||
PD | 108 | 1.896 | 0.799 | ||||||
IQR right STANCE % | HS | 88 | 1.229 | 0.337 | −7.009 | 194 | <0.001 * | ||
PD | 108 | 1.905 | 0.852 | ||||||
IQR DOUBLE SUPPORT | HS | 88 | 0.013 | 0.008 | −2.875 | 194 | 0.004 | ||
PD | 108 | 0.018 | 0.014 | ||||||
IQR_DOUBLE_SUPPORT % | HS | 88 | 1.141 | 0.502 | −3.446 | 194 | <0.001 * | ||
PD | 108 | 1.613 | 1.203 |
Variables | AUC | Standard Error | p Value | Lower Limit | Upper Limit |
---|---|---|---|---|---|
Gait Speed (m/s) | 0.200 | 0.035 | <0.001 * | 0.130 | 0.269 |
Time Up and Go (s) | 0.801 | 0.036 | <0.001 * | 0.730 | 0.872 |
SD left SWING | 0.682 | 0.044 | <0.001 * | 0.595 | 0.768 |
SD right SWING | 0.703 | 0.043 | <0.001 * | 0.620 | 0.787 |
SD left SWING % | 0.674 | 0.045 | <0.001 * | 0.585 | 0.763 |
SD right SWING % | 0.740 | 0.041 | <0.001 * | 0.660 | 0.819 |
SD left STANCE % | 0.674 | 0.045 | <0.001 * | 0.585 | 0.763 |
SD right STANCE % | 0.740 | 0.041 | <0.001 * | 0.660 | 0.819 |
SD DOUBLE SUPPORT% | 0.643 | 0.039 | <0.001 * | 0.566 | 0.720 |
IQR left SWING | 0.778 | 0.037 | <0.001 * | 0.704 | 0.851 |
IQR right SWING | 0.733 | 0.041 | <0.001 * | 0.654 | 0.813 |
IQR left SWING % | 0.776 | 0.037 | <0.001 * | 0.703 | 0.848 |
IQR right SWING % | 0.820 | 0.034 | <0.001 * | 0.754 | 0.886 |
IQR left STANCE | 0.639 | 0.045 | 0.0036 | 0.551 | 0.727 |
IQR right STANCE | 0.667 | 0.044 | <0.001 * | 0.580 | 0.754 |
IQR left STANCE % | 0.776 | 0.037 | <0.001 * | 0.703 | 0.848 |
IQR right STANCE % | 0.820 | 0.034 | <0.001 * | 0.754 | 0.886 |
IQR DOUBLE SUPPORT % | 0.634 | 0.040 | 0.0012 | 0.556 | 0.712 |
Variables | Group | N | Average | Standard Deviation | t | df | p Value | ||
---|---|---|---|---|---|---|---|---|---|
dynamic | central tendency indices | Ave Force left | HS | 88 | 372.346 | 181.982 | −0.813 | 194 | 0.417 |
PD | 108 | 392.385 | 162.683 | ||||||
Ave Force right | HS | 88 | 369.036 | 181.877 | −1.044 | 194 | 0.298 | ||
PD | 108 | 394.455 | 158.804 | ||||||
Med Force left | HS | 88 | 467.395 | 235.065 | −0.537 | 194 | 0.592 | ||
PD | 108 | 484.518 | 210.938 | ||||||
Med Force right | HS | 88 | 459.291 | 235.530 | −1.025 | 194 | 0.307 | ||
PD | 108 | 491.887 | 209.364 | ||||||
dispersion indices | SD Force left | HS | 88 | 324.871 | 160.322 | −0.561 | 194 | 0.576 | |
PD | 108 | 336.977 | 141.656 | ||||||
SD Force right | HS | 88 | 324.106 | 160.490 | −0.608 | 194 | 0.544 | ||
PD | 108 | 337.011 | 136.732 | ||||||
IQR Force left | HS | 88 | 671.779 | 332.736 | −0.764 | 194 | 0.446 | ||
PD | 108 | 706.230 | 297.570 | ||||||
IQR Force right | HS | 88 | 671.246 | 332.261 | −0.877 | 194 | 0.382 | ||
PD | 108 | 710.175 | 288.892 |
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di Biase, L.; Raiano, L.; Caminiti, M.L.; Pecoraro, P.M.; Di Lazzaro, V. Parkinson’s Disease Wearable Gait Analysis: Kinematic and Dynamic Markers for Diagnosis. Sensors 2022, 22, 8773. https://doi.org/10.3390/s22228773
di Biase L, Raiano L, Caminiti ML, Pecoraro PM, Di Lazzaro V. Parkinson’s Disease Wearable Gait Analysis: Kinematic and Dynamic Markers for Diagnosis. Sensors. 2022; 22(22):8773. https://doi.org/10.3390/s22228773
Chicago/Turabian Styledi Biase, Lazzaro, Luigi Raiano, Maria Letizia Caminiti, Pasquale Maria Pecoraro, and Vincenzo Di Lazzaro. 2022. "Parkinson’s Disease Wearable Gait Analysis: Kinematic and Dynamic Markers for Diagnosis" Sensors 22, no. 22: 8773. https://doi.org/10.3390/s22228773