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Article

Development of a New Integrated System for Vital Sign Monitoring in Small Animals

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Institute for Nanostructures, Nanomodelling and Nanofabrication (i3N), Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal
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Radiation Imaging Technologies Lda. (RI-TE), University of Aveiro Incubator, PCI—Creative Science Park, 3830-352 Ílhavo, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Alessandro Bevilacqua
Sensors 2022, 22(11), 4264; https://doi.org/10.3390/s22114264
Received: 26 April 2022 / Revised: 22 May 2022 / Accepted: 1 June 2022 / Published: 3 June 2022
(This article belongs to the Section Sensing and Imaging)
Monitoring the vital signs of mice is an essential practice during imaging procedures to avoid populational losses and improve image quality. For this purpose, a system based on a set of devices (piezoelectric sensor, optical module and thermistor) able to detect the heart rate, respiratory rate, body temperature and arterial blood oxygen saturation (SpO2) in mice anesthetized with sevoflurane was implemented. Results were validated by comparison with the reported literature on similar anesthetics. A new non-invasive electrocardiogram (ECG) module was developed, and its first results reflect the viability of its integration in the system. The sensors were strategically positioned on mice, and the signals were acquired through a custom-made printed circuit board during imaging procedures with a micro-PET (Positron Emission Tomography). For sevoflurane concentration of 1.5%, the average values obtained were: 388 bpm (beats/minute), 124 rpm (respirations/minute) and 88.9% for the heart rate, respiratory rate and SpO2, respectively. From the ECG information, the value obtained for the heart rate was around 352 bpm for injectable anesthesia. The results compare favorably to the ones established in the literature, proving the reliability of the proposed system. The ECG measurements show its potential for mice heart monitoring during imaging acquisitions and thus for integration into the developed system. View Full-Text
Keywords: body temperature; heart rate; Positron Emission Tomography (PET); respiratory rate; small animal imaging; vital sign monitoring body temperature; heart rate; Positron Emission Tomography (PET); respiratory rate; small animal imaging; vital sign monitoring
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MDPI and ACS Style

Oliveira, R.G.; Correia, P.M.M.; Silva, A.L.M.; Encarnação, P.M.C.C.; Ribeiro, F.M.; Castro, I.F.; Veloso, J.F.C.A. Development of a New Integrated System for Vital Sign Monitoring in Small Animals. Sensors 2022, 22, 4264. https://doi.org/10.3390/s22114264

AMA Style

Oliveira RG, Correia PMM, Silva ALM, Encarnação PMCC, Ribeiro FM, Castro IF, Veloso JFCA. Development of a New Integrated System for Vital Sign Monitoring in Small Animals. Sensors. 2022; 22(11):4264. https://doi.org/10.3390/s22114264

Chicago/Turabian Style

Oliveira, Regina G., Pedro M.M. Correia, Ana L.M. Silva, Pedro M.C.C. Encarnação, Fabiana M. Ribeiro, Ismael F. Castro, and João F.C.A. Veloso. 2022. "Development of a New Integrated System for Vital Sign Monitoring in Small Animals" Sensors 22, no. 11: 4264. https://doi.org/10.3390/s22114264

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