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Article

Highly Sensitive and Cost-Effective Portable Sensor for Early Gastric Carcinoma Diagnosis

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State Key Laboratory for THz and Millimeter Waves and Department of Material Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong, China
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Department of Physics, City University of Hong Kong, Kowloon, Hong Kong, China
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Department of Biomedical Science, City University of Hong Kong, Kowloon, Hong Kong, China
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Institute for Bioengineering, School of Engineering, The University of Edinburgh, King’s Buildings, Mayfield Road, Edinburgh EH9 3JL, UK
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James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK
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Authors to whom correspondence should be addressed.
Sensors 2021, 21(8), 2639; https://doi.org/10.3390/s21082639
Received: 10 February 2021 / Revised: 23 March 2021 / Accepted: 25 March 2021 / Published: 9 April 2021
(This article belongs to the Section Biomedical Sensors)
Facile and efficient early detection of cancer is a major challenge in healthcare. Herein we developed a novel sensor made from a polycarbonate (PC) membrane with nanopores, followed by sequence-specific Oligo RNA modification for early gastric carcinoma diagnosis. In this design, the gastric cancer antigen CA72-4 is specifically conjugated to the Oligo RNA, thereby inhibiting the electrical current through the PC membrane in a concentration-dependent manner. The device can determine the concentration of cancer antigen CA72-4 in the range from 4 to 14 U/mL, possessing a sensitivity of 7.029 µAU−1mLcm−2 with a linear regression (R2) of 0.965 and a lower detection limit of 4 U/mL. This device has integrated advantages including high specificity and sensitivity and being simple, portable, and cost effective, which collectively enables a giant leap for cancer screening technologies towards clinical use. This is the first report to use RNA aptamers to detect CA72-4 for gastric carcinoma diagnosis. View Full-Text
Keywords: polycarbonate membrane; cancer antigen; Oligo RNA; cancer early detection; electrical current sensor polycarbonate membrane; cancer antigen; Oligo RNA; cancer early detection; electrical current sensor
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MDPI and ACS Style

Oo, S.-L.; Venkatesh, S.; Karthikeyan, V.; Arava, C.M.; Pathikonda, S.; Yu, P.K.N.; Lau, T.C.K.; Chen, X.; Roy, V.A.L. Highly Sensitive and Cost-Effective Portable Sensor for Early Gastric Carcinoma Diagnosis. Sensors 2021, 21, 2639. https://doi.org/10.3390/s21082639

AMA Style

Oo S-L, Venkatesh S, Karthikeyan V, Arava CM, Pathikonda S, Yu PKN, Lau TCK, Chen X, Roy VAL. Highly Sensitive and Cost-Effective Portable Sensor for Early Gastric Carcinoma Diagnosis. Sensors. 2021; 21(8):2639. https://doi.org/10.3390/s21082639

Chicago/Turabian Style

Oo, Saw-Lin, Shishir Venkatesh, Vaithinathan Karthikeyan, Clement M. Arava, Spoorthy Pathikonda, Peter K.N. Yu, Terrence C.K. Lau, Xianfeng Chen, and Vellaisamy A.L. Roy 2021. "Highly Sensitive and Cost-Effective Portable Sensor for Early Gastric Carcinoma Diagnosis" Sensors 21, no. 8: 2639. https://doi.org/10.3390/s21082639

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