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Article

Smartphone-Based Device for Colorimetric Detection of MicroRNA Biomarkers Using Nanoparticle-Based Assay

by 1,2, 1,2 and 1,2,3,*
1
Fitzpatrick Institute for Photonics, Duke University, Durham, NC 27708, USA
2
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
3
Department of Chemistry, Duke University, Durham, NC 27708, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Kai Wu, Jinming Liu and Diqing Su
Sensors 2021, 21(23), 8044; https://doi.org/10.3390/s21238044
Received: 29 October 2021 / Revised: 23 November 2021 / Accepted: 27 November 2021 / Published: 1 December 2021
(This article belongs to the Special Issue Advanced Nanomaterial-Based Sensors for Biomedical Applications)
The detection of microRNAs (miRNAs) is emerging as a clinically important tool for the non-invasive detection of a wide variety of diseases ranging from cancers and cardiovascular illnesses to infectious diseases. Over the years, miRNA detection schemes have become accessible to clinicians, but they still require sophisticated and bulky laboratory equipment and trained personnel to operate. The exceptional computing ability and ease of use of modern smartphones coupled with fieldable optical detection technologies can provide a useful and portable alternative to these laboratory systems. Herein, we present the development of a smartphone-based device called Krometriks, which is capable of simple and rapid colorimetric detection of microRNA (miRNAs) using a nanoparticle-based assay. The device consists of a smartphone, a 3D printed accessory, and a custom-built dedicated mobile app. We illustrate the utility of Krometriks for the detection of an important miRNA disease biomarker, miR-21, using a nanoplasmonics-based assay developed by our group. We show that Krometriks can detect miRNA down to nanomolar concentrations with detection results comparable to a laboratory-based benchtop spectrophotometer. With slight changes to the accessory design, Krometriks can be made compatible with different types of smartphone models and specifications. Thus, the Krometriks device offers a practical colorimetric platform that has the potential to provide accessible and affordable miRNA diagnostics for point-of-care and field applications in low-resource settings. View Full-Text
Keywords: smartphone-based device; colorimetric analysis; miRNA detection; medical diagnostics; cancer detection; biofuel research smartphone-based device; colorimetric analysis; miRNA detection; medical diagnostics; cancer detection; biofuel research
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MDPI and ACS Style

Krishnan, T.; Wang, H.-N.; Vo-Dinh, T. Smartphone-Based Device for Colorimetric Detection of MicroRNA Biomarkers Using Nanoparticle-Based Assay. Sensors 2021, 21, 8044. https://doi.org/10.3390/s21238044

AMA Style

Krishnan T, Wang H-N, Vo-Dinh T. Smartphone-Based Device for Colorimetric Detection of MicroRNA Biomarkers Using Nanoparticle-Based Assay. Sensors. 2021; 21(23):8044. https://doi.org/10.3390/s21238044

Chicago/Turabian Style

Krishnan, Tushar, Hsin-Neng Wang, and Tuan Vo-Dinh. 2021. "Smartphone-Based Device for Colorimetric Detection of MicroRNA Biomarkers Using Nanoparticle-Based Assay" Sensors 21, no. 23: 8044. https://doi.org/10.3390/s21238044

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