Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Muscle Strength Testing and Physical Symptom Assessment
2.3. Electromyography (EMG) Recording
2.4. Data Processing
2.5. DAT-SPECT
2.6. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | Females with Parkinson’s Disease |
---|---|
Age, years | 72.6 ± 7.2 |
Height, cm | 157.1 ± 10.2 |
Weight, kg | 58.3 ± 6.8 |
Disease duration, year | 3.5 ± 2.1 |
MMSE | 26.6 ± 1.4 |
UPDRS Part III | 9.9 ± 9.1 |
L-dopa, mg/day | 300 (100–300) |
Knee extensor muscle strength, Nm More-/Less-affected side | 54.3 ± 9.9/72.9 ± 20.5 * |
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Nishikawa, Y.; Watanabe, K.; Holobar, A.; Takahashi, T.; Maeda, N.; Maruyama, H.; Tanaka, S.; Hyngstrom, A.S. Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients. Sensors 2021, 21, 6615. https://doi.org/10.3390/s21196615
Nishikawa Y, Watanabe K, Holobar A, Takahashi T, Maeda N, Maruyama H, Tanaka S, Hyngstrom AS. Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients. Sensors. 2021; 21(19):6615. https://doi.org/10.3390/s21196615
Chicago/Turabian StyleNishikawa, Yuichi, Kohei Watanabe, Aleš Holobar, Tetsuya Takahashi, Noriaki Maeda, Hirofumi Maruyama, Shinobu Tanaka, and Allison S Hyngstrom. 2021. "Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients" Sensors 21, no. 19: 6615. https://doi.org/10.3390/s21196615